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Showing 1–1 of 1 results
Advanced filters: Author: Célia M. Guérin Clear advanced filters

  • In patients with melanoma, increased RAS/mitogen-activated protein kinase (MAPK) pathway activity is known to drive chemotherapy resistance. Here, the authors identify CDK12 as a downstream effector of the RAS/MAPK pathway and therapeutic target which mediates chemotherapy resistance through increased expression of DNA repair associated genes.

    • Thibault Houles
    • Geneviève Lavoie
    • Philippe P. Roux
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16