Pax5 is a transcription factor important for B cell differentiation and function. Deletion of Pax5 in mature B cells causes them to de-differentiate to less differentiated progenitor cells that can give rise to T cells, demonstrating an unanticipated degree of developmental plasticity in this lineage.
- César Cobaleda
- Wolfram Jochum
- Meinrad Busslinger
