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Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor

E Sugihara
T Shimizu
H Saya
Research10 Oct 2011
Oncogene

Volume: 31, P: 2849-2861
CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

Y Kong
S Yoshida
F Ishikawa
Research17 Apr 2008
Leukemia

Volume: 22, P: 1207-1213
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma

Diffuse large B-cell lymphoma is an aggressive heterogeneous tumour type with poorly understood aetiology. Here, Green et al. show that transient expression of Bcl6in haematopoietic stem cells is sufficient to induce mature B-cell lymphoma, indicating that it acts as a ‘hit-and-run’ oncogene.

Michael R. Green
Carolina Vicente-Dueñas
Isidro Sánchez-García
Research02 Jun 2014
Nature Communications

Volume: 5, P: 1-13
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

B cell development requires interleukin 7 signals that activate the transcription factor STAT5. Busslinger and colleagues report that STAT5 has a permissive rather than instructive role in pro-B cell survival and immunoglobulin recombination.

Stephen Malin
Shane McManus
Meinrad Busslinger
Research29 Nov 2009
Nature Immunology

Volume: 11, P: 171-179
Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein is mediated by PAX5

D A Casolari
M Makri
J V Melo
Research03 Aug 2012
Leukemia

Volume: 27, P: 409-415
Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

Marta Isidro-Hernández
Andrea Mayado
Isidro Sánchez-García
ResearchOpen Access05 Nov 2020
Scientific Reports

Volume: 10, P: 1-14
Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency. Here the authors perform single-cell omics analyses in CVID-discordant monozygotic twins and show epigenetic and transcriptional alterations associated with activation in memory B cells.

Javier Rodríguez-Ubreva
Anna Arutyunyan
Esteban Ballestar
ResearchOpen Access01 Apr 2022
Nature Communications

Volume: 13, P: 1-18
Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5

K Walter
P N Cockerill
H Tagoh
Research08 Mar 2010
Oncogene

Volume: 29, P: 2927-2937
Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

C Virely
S Moulin
J Ghysdael
Correspondence15 Apr 2010
Leukemia

Volume: 24, P: 1200-1204
Research recommendations toward a better understanding of the causes of childhood leukemia

G Ziegelberger
C Baum
W Weiss
News & ViewsOpen Access28 Jan 2011
Blood Cancer Journal

Volume: 1, P: e1

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Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor

CD34+CD38+CD19+ as well as CD34+CD38−CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL

Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

Transcriptional suppression of BACH2 by the Bcr-Abl oncoprotein is mediated by PAX5

Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis

Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5

Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia

Research recommendations toward a better understanding of the causes of childhood leukemia

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