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Showing 1–7 of 7 results
Advanced filters: Author: C D Robles-Espinoza Clear advanced filters
  • Mucosal melanoma is a rare melanoma subtype that is poorly characterised. Here, the authors sequenced human, canine, and equine melanoma samples and performed a cross-species analysis, which revealed candidate driver genes, recurrent copy number alterations in regions syntenic between species, extensive intra-tumour heterogeneity and potential germline predisposing alleles

    • Kim Wong
    • Louise van der Weyden
    • David J. Adams
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14
  • David Adams, Julia Newton-Bishop, Timothy Bishop, Nicholas Hayward and colleagues identify loss-of-function variants in POT1 in several families with early onset multiple primary melanoma. They further show that these variants disrupt telomere binding by POT1 and are associated with increased telomere length.

    • Carla Daniela Robles-Espinoza
    • Mark Harland
    • David J Adams
    Research
    Nature Genetics
    Volume: 46, P: 478-481
  • Frequency of cancer-related gene mutations can vary between populations. Here, the authors show differences in TP53 and other gene mutations between the U.S. and Chinese patients, and analyse differences in environmental risk factors to demonstrate that population-specific factors should be considered when discussing cancer risk.

    • Fayang Ma
    • Kyle Laster
    • Zigang Dong
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • Most of our current knowledge of melanoma is derived from the study of patients from populations of European descent, for whom public health, sun protection initiatives and screening measures have appreciably decreased disease mortality. Notably, some melanoma subtypes that most commonly develop in other populations are not associated with exposure to ultraviolet (UV) light, suggesting a different disease aetiology. Further study of these subtypes is necessary to understand their risk factors and genomic architecture, and to tailor therapies and public health campaigns to benefit patients of all ethnic groups.

    • Raul Ossio
    • Rodrigo Roldán-Marín
    • Carla Daniela Robles-Espinoza
    Comments & Opinion
    Nature Reviews Cancer
    Volume: 17, P: 393-394