The mechanisms behind therapy-related myeloid neoplasms (t-MN) occurring after chemotherapy treatment remain poorly understood, particularly for paediatric patients. Here, the authors analyse t-MN in children using single-cell genomics, showing how t-MN founding cells can expand after cessation of therapy and how the platinum-induced growth inhibition is TP53-dependent.
- Eline J. M. Bertrums
- Jurrian K. de Kanter
- Ruben van Boxtel
