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Showing 1–50 of 96 results

Advanced filters: Author: C T M van Rossum Clear advanced filters

Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells

Fusobacterium nucleatum promotes colorectal cancer via its adhesin Fap2. Here, Schöpf et al. show the molecular basis for Fap2 interaction with its receptors TIGIT on immune cells and Gal-GalNAc on tumor cells using cryo-EM and integrative modeling.

Felix Schöpf
Gian L. Marongiu
Daniel Roderer
ResearchOpen Access29 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Allozyme variation in relation to ecotypic differentiation and population size in marginal populations of Silene nutans

Fabienne van Rossum
Xavier Vekemans
Claude Lefèbvre
Research01 May 1997
Heredity

Volume: 78, P: 552-560
Isolation of a candidate gene for Norrie disease by positional cloning

W. Berger
A. Meindl
T. Meitinger
Research01 Jun 1992
Nature Genetics

Volume: 1, P: 199-203
Cellular and synaptic phenotypes lead to disrupted information processing in Fmr1-KO mouse layer 4 barrel cortex

Somatosensory hypersensitivity in Fmr-1 knockout mice is thought to arise from an increase in cortical circuit excitability. Here, the authors report that the loss of precision of sensory encoding in the Layer 4 of barrel cortex is the primary developmental circuit alteration that drives the other compensatory circuit dysfunction.

Aleksander P. F. Domanski
Sam A. Booker
Peter C. Kind
ResearchOpen Access23 Oct 2019
Nature Communications

Volume: 10, P: 1-18
Mesoscopic light transport by very strong collective multiple scattering in nanowire mats

Researchers report that light flow is strongly affected by mesoscopic interference in semiconducting nanowire mats in which the scattering length is much shorter than the wavelength of light. By measuring intensity distributions, fluctuations and correlations, they obtain evidence of low conductance and signatures of the onset of Anderson localization.

Tom Strudley
Tilman Zehender
Otto L. Muskens
Research07 Apr 2013
Nature Photonics

Volume: 7, P: 413-418
Structure of Acetylcholine and Other Substrates of Cholinergic Systems

F. G. CANEPA
PETER PAULING
H. SÖRUM
Research28 May 1966
Nature

Volume: 210, P: 907-909
Is actin in eye lens a possible factor in visual accommodation?

M. A. Kibbelaar
F. C. S. Ramaekers
H. Bloemendal
Research12 Jun 1980
Nature

Volume: 285, P: 506-508
Stimulant effects of enkephalin microinjection into the dopaminergic A10 area

C. L. E. BROEKKAMP
A. G. PHILLIPS
A. R. COOLS
Research01 Apr 1979
Nature

Volume: 278, P: 560-562
Utilization of High-Energy Intermediates of Oxidative Phosphorylation and the Proposed Function of Imidazole Phosphate as an Intermediate in Oxidative Phosphorylation

E. C. SLATER
A. KEMP jun.
J. M. TAGER
Research22 Feb 1964
Nature

Volume: 201, P: 781-784
Retinal degeneration in the rd mouse is caused by a defect in the β subunit of rod cGMP-phosphodiesterase

Cathy Bowes
Tiansen Li
Debora B. Farber
Research18 Oct 1990
Nature

Volume: 347, P: 677-680
Effect of balancing selection on spatial genetic structure within populations: theoretical investigations on the self-incompatibility locus and empirical studies in Arabidopsis halleri

J-B Leducq
V Llaurens
X Vekemans
Research09 Jun 2010
Heredity

Volume: 106, P: 319-329
Domoic and quisqualic acids as potent amino acid excitants of frog and rat spinal neurones

T. J. BISCOE
R. H. EVANS
J. C. WATKINS
Research08 May 1975
Nature

Volume: 255, P: 166-167
Cationic Forms of Local Anaesthetics block Action Potentials from Inside the Nerve Membrane

TOSHIO NARAHASHI
MINORU YAMADA
DONALD T. FRAZIER
Research16 Aug 1969
Nature

Volume: 223, P: 748-749
Phylogeographic pattern of range expansion provides evidence for cryptic species lineages in Silene nutans in Western Europe

H Martin
P Touzet
J-F Arnaud
Research09 Dec 2015
Heredity

Volume: 116, P: 286-294
Immunochemical faecal occult blood test: number of samples and positivity cutoff. What is the best strategy for colorectal cancer screening?

G Grazzini
C B Visioli
M Zappa
ResearchOpen Access13 Jan 2009
British Journal of Cancer

Volume: 100, P: 259-265
Screening for colorectal cancer: random comparison of guaiac and immunochemical faecal occult blood testing at different cut-off levels

L Hol
J A Wilschut
M E van Leerdam
ResearchOpen Access31 Mar 2009
British Journal of Cancer

Volume: 100, P: 1103-1110
A Second Molecular Species of Mouse Interferon in Mice injected with Statolon

THOMAS C. MERIGAN
W. J. KLEINSCHMIDT
Research17 Dec 1966
Nature

Volume: 212, P: 1383-1384
Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro

C. J. Hanna
M. K. Bach
R. R. Schellenberg
Research26 Mar 1981
Nature

Volume: 290, P: 343-344
Control of criticality and computation in spiking neuromorphic networks with plasticity

Designing efficient artificial networks able to quickly converge to optimal performance for a given task remains a challenge. Here, the authors demonstrate a relation between criticality, task-performance and information theoretic fingerprint in a spiking neuromorphic network with synaptic plasticity.

Benjamin Cramer
David Stöckel
Viola Priesemann
ResearchOpen Access05 Jun 2020
Nature Communications

Volume: 11, P: 1-11
SciPy 1.0: fundamental algorithms for scientific computing in Python

This Perspective describes the development and capabilities of SciPy 1.0, an open source scientific computing library for the Python programming language.

Pauli Virtanen
Ralf Gommers
Yoshiki Vázquez-Baeza
ReviewsOpen Access03 Feb 2020
Nature Methods

Volume: 17, P: 261-272
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer

The phase 3 SONIA trial challenges the benefits of using cyclin-dependent kinase 4 and 6 inhibitors as a first-line compared with second-line treatment.

Gabe S. Sonke
Annemiek van Ommen-Nijhof
Christa van Schaik-van de Mheen
Research27 Nov 2024
Nature

Volume: 636, P: 474-480
The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage.

Laura Bornes
Lennart J. van Winden
Jacco van Rheenen
ResearchOpen Access04 Dec 2024
Nature

Volume: 637, P: 195-204
Cooperative Effect of Certain Anaesthetics on the Lobster Giant Axon

C. SCHAUF
D. AGIN
Research22 Feb 1969
Nature

Volume: 221, P: 768-769
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

J. R. S. Arch
A. T. Ainsworth
S. Wilson
Research10 May 1984
Nature

Volume: 309, P: 163-165
Neuromyelitis optica

D C Burke
D J E Cheshire
Research01 Aug 1968
Spinal Cord

Volume: 6, P: 79-89
Inhibition by Ouabain of Glycolysis in Ciliary Body

M. V. RILEY
Research01 Oct 1964
Nature

Volume: 204, P: 380
Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor

K. Tsuruta
E. A. Frey
J. W. Kebabian
Research30 Jul 1981
Nature

Volume: 292, P: 463-465
α-Actinin-containing branched microvilli isolated from an ascites adenocarcinoma

K. L. Carraway
J. W. Huggins
C. A. Carothers Carraway
Research12 Jun 1980
Nature

Volume: 285, P: 508-510
Short-term molecular consequences of chromosome mis-segregation for genome stability

Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.

Lorenza Garribba
Giuseppina De Feudis
Stefano Santaguida
ResearchOpen Access11 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Neural Tissue and Pulmonary Lesions in Normal and Irradiated Rats injected with Homogenized Homologous Lung Tissue mixed with Freund's Adjuvant

N. ALLEGRETTI
B. VITALE
Research25 Feb 1961
Nature

Volume: 189, P: 673
Maturational Changes in the Pharmacological Characteristics and Actomyosin Content of Canine Arterial and Venous Tissue

C L Seidel
B Ross
T Miller
Research01 Feb 1987
Pediatric Research

Volume: 21, P: 152-158
Anti-muscarinic properties of neuroleptics and drug-induced Parkinsonism

RICHARD J. MILLER
C. ROBIN HILEY
Research12 Apr 1974
Nature

Volume: 248, P: 596-597
Prostaglandin Antagonists: Synthesis and Smooth Muscle Activity

JOSEF FRIED
T. S. SANTHANAKRISHNAN
E. O. GRIGAS
Research12 Jul 1969
Nature

Volume: 223, P: 208-210
The structural and functional connectivity of the grassland plant Lychnis flos-cuculi

T Aavik
R Holderegger
J Bolliger
Research20 Nov 2013
Heredity

Volume: 112, P: 471-478
Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events

Phosphorylation of residues in the N-terminal tail of histone H3 signals different biological outcomes. High-resolution NMR analyses now reveal a mechanistic hierarchy of H3 phosphorylation events, whereby phosphorylation of Ser10 impedes the phosphorylation of Thr6 and Thr11 by PKC and Chk1, respectively. Because both enzymes also target Ser10, this establishes an autoinhibitory feedback loop on H3 tails.

Stamatios Liokatis
Alexandra Stützer
Philipp Selenko
Research15 Jul 2012
Nature Structural & Molecular Biology

Volume: 19, P: 819-823
Perception of Contours in the Central Fovea

D. P. ANDREWS
Research01 Mar 1965
Nature

Volume: 205, P: 1218-1220
Combined effects of adrenaline and insulin on active electrogenic Na⁺–K⁺ transport in rat soleus muscle

J. A. Flatman
T. Clausen
Research01 Oct 1979
Nature

Volume: 281, P: 580-581
Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma

Immune checkpoint blockade has become standard care for patients with recurrent metastatic head and neck squamous cell carcinoma (HNSCC). Here the authors present the results of a non-randomized phase Ib/IIa trial, reporting safety and efficacy of neoadjuvant nivolumab monotherapy and nivolumab plus ipilimumab prior to standard-of-care surgery in patients with HNSCC. .

Joris L. Vos
Joris B. W. Elbers
Charlotte L. Zuur
ResearchOpen Access22 Dec 2021
Nature Communications

Volume: 12, P: 1-13
Ureaplasma parvum and Ureaplasma urealyticum induce distinct types of inflammation in neonates and human epithelial cell models

Hongzhen Zhu
Pol Oliveras-Julià
Wendy W. J. Unger
ResearchOpen Access03 Oct 2025
Pediatric Research

P: 1-10
Ratio Dependent Synergism in Azo-dye Carcinogenesis

J C Arcos
G W Griffith
Research01 Jun 1961
British Journal of Cancer

Volume: 15, P: 291-298
Aberrant mRNA in Parkinsonism: Support for Hypothesis from Studies with Chloramphenicol

C. N. STEFANIS
M. ISSIDORIDES
Research07 Mar 1970
Nature

Volume: 225, P: 962-963
Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation

Lucas and colleagues describe loss-of-function variants in the X-linked ETS transcription factor ELF4 in multiple unrelated male patients with early onset mucosal autoinflammation and inflammatory bowel disease (IBD)-like features.

Paul M. Tyler
Molly L. Bucklin
Carrie L. Lucas
Research29 Jul 2021
Nature Immunology

Volume: 22, P: 1118-1126
Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

The mechanisms by which measles virus infection induces transient immune suppression in humans are poorly understood. Here, Laksono and colleagues characterise the pathogenesis of measles-associated immune suppression in unvaccinated children, and shed new light on the long-term effects of measles on the host.

Brigitta M. Laksono
Rory D. de Vries
Rik L. de Swart
ResearchOpen Access23 Nov 2018
Nature Communications

Volume: 9, P: 1-10
Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an α-conotoxin PnIA variant

Patrick H N Celie
Igor E Kasheverov
August B Smit
Research12 Jun 2005
Nature Structural & Molecular Biology

Volume: 12, P: 582-588
The companion of cellulose synthase 1 confers salt tolerance through a Tau-like mechanism in plants

The Arabidopsis CC1 protein maintains microtubule array stability and cellulose synthesis during salt stress. Here the authors show that CC1 engages microtubules via an intrinsically disordered N-terminus that suggests it controls microtubule dynamics in a similar way to the mammalian Tau protein.

Christopher Kesten
Arndt Wallmann
Staffan Persson
ResearchOpen Access20 Feb 2019
Nature Communications

Volume: 10, P: 1-14
Large-scale genome-wide association analyses identify novel genetic loci and mechanisms in hypertrophic cardiomyopathy

Genome-wide and multitrait analyses identify novel loci associated with hypertrophic cardiomyopathy and relevant left ventricular traits. Gene-level burden analyses show that rare truncating SVIL variants are associated with high risk of hypertrophic cardiomyopathy.

Rafik Tadros
Sean L. Zheng
Hugh Watkins
ResearchOpen Access18 Feb 2025
Nature Genetics

Volume: 57, P: 530-538
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51

Fanconi anaemia is an inherited disorder characterised by developmental abnormalities, bone marrow failure and predisposition to cancer. Here the authors report a de novo mutation in the DNA repair gene Rad51in an atypical subtype of Fanconi anaemia.

Najim Ameziane
Patrick May
Josephine C. Dorsman
ResearchOpen Access18 Dec 2015
Nature Communications

Volume: 6, P: 1-11
Obesity and metabolic syndrome in adults with a 22q11.2 microdeletion

Hester Jaspers Faijer-Westerink
Emma N. M. M. von Scheibler
Erik Boot
ResearchOpen Access30 Nov 2024
International Journal of Obesity

Volume: 49, P: 642-648
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour

TRPs are calcium-permeable channels involved in the sensing of damaging stimuli but the relationship between calcium influx and pain behaviour has been elusive. Here the authors find that the TRP channel OSM-9 functions as an ion channel in vivo in C. elegans, and establish residues that are critical for worm pain-like behaviour.

Amanda S. Lindy
Puja K. Parekh
Wolfgang B. Liedtke
ResearchOpen Access02 Sept 2014
Nature Communications

Volume: 5, P: 1-13
Event Horizon Telescope observations of the jet launching and collimation in Centaurus A

The millimetre image of the Centaurus A nucleus by the Event Horizon Telescope reveals a highly collimated, asymmetrically edge-brightened jet. The source’s event horizon shadow should be visible at terahertz frequencies, consistent with the universal scale invariance of black holes.

Michael Janssen
Heino Falcke
Shan-Shan Zhao
ResearchOpen Access19 Jul 2021
Nature Astronomy

Volume: 5, P: 1017-1028

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