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Showing 101–150 of 639 results

Advanced filters: Author: C Uchida Clear advanced filters

Evaluation of tirandamycins with selective activity against Enterococci in the silkworm infection model

Akiho Yagi
Taku Sato
Ryuji Uchida
Research14 Feb 2025
The Journal of Antibiotics

Volume: 78, P: 211-218
Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides

Naturally occurring peptides with high membrane permeability often have backbone ester bonds. Here, the authors investigated the effect of an amide-to-ester substitution on membrane permeability of peptides and found the substitution is useful for improving membrane permeability of cyclic peptides.

Yuki Hosono
Satoshi Uchida
Shinsuke Sando
ResearchOpen Access17 Mar 2023
Nature Communications

Volume: 14, P: 1-14
Charge-density-wave order takes over antiferromagnetism in Bi₂Sr_2−xLa_xCuO₆ superconductors

Whilst superconductivity usually appears when magnetic order is suppressed, the role of charge is less known. Here, Kawasaki et al. report a charge density wave (CDW) above the superconducting transition induced by an in-plane magnetic field in Bi₂Sr_2-xLa_xCuO₆, with the CDW onset temperature scaling with the pseudogap temperature.

S. Kawasaki
Z. Li
Guo-qing Zheng
ResearchOpen Access02 Nov 2017
Nature Communications

Volume: 8, P: 1-7
Efficacy and safety of esaxerenone with and without sodium–glucose cotransporter-2 inhibitor use in hypertensive patients with type 2 diabetes mellitus: a pooled analysis of five clinical studies

Hirohiko Motoki
Koichiro Kuwahara
Takashi Taguchi
ResearchOpen Access01 Sept 2025
Hypertension Research

P: 1-14
Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Preclinical studies show that fluoxazolevir, which inhibits the fusion of hepatitis C virus (HCV) with hepatic cells by binding viral envelope protein 1, could be useful in drug cocktails to treat HCV.

Christopher D. Ma
Michio Imamura
Tsanyang Jake Liang
Research31 Aug 2020
Nature Microbiology

Volume: 5, P: 1532-1541
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo

Next-generation red and green G-protein-coupled receptor-based dopamine sensors with improved properties have been developed. Their performance is demonstrated in cell culture, in brain slices and in vivo in the mouse.

Yizhou Zhuo
Bin Luo
Yulong Li
Research30 Nov 2023
Nature Methods

Volume: 21, P: 680-691
Functional expression and germline atransmission of a human chromosome fragment in chimaeric mice

Kazuma Tomizuka
Hitoshi Yoshida
Isao Ishida
Research01 Jun 1997
Nature Genetics

Volume: 16, P: 133-143
Structure Elucidation of Fungal Sespendole, an Inhibitor of Lipid Droplet Synthesis in Macrophages

Ryuji Uchida
Yong-Pil Kim
Satoshi Ōmura
Research01 Jun 2006
The Journal of Antibiotics

Volume: 59, P: 338-344
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

Margaret A. Goodell
Michael Rosenzweig
R. Paul Johnson
Research01 Dec 1997
Nature Medicine

Volume: 3, P: 1337-1345
Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase

P Cuq
C Rouquet
J-P Cano
ResearchOpen Access12 Jun 2001
British Journal of Cancer

Volume: 84, P: 1677-1680
Infrequent involvement of p53 gene mutations in the tumourigenesis of Japanese prostate cancer

T Uchida
C Wada
K Koshiba
Research01 Oct 1993
British Journal of Cancer

Volume: 68, P: 751-755
SOX17-positive rete testis epithelium is required for Sertoli valve formation and normal spermiogenesis in the male mouse

A valve-like structure called this Sertoli valve (SV) supports spermatogenesis by modulating the directional fluid flow in mouse testis. The SV formation is supported by its neighboring SOX17 + rete testis (RT). This study highlights the essential roles of RT and SV in spermatogenesis.

Aya Uchida
Kenya Imaimatsu
Yoshiakira Kanai
ResearchOpen Access21 Dec 2022
Nature Communications

Volume: 13, P: 1-14
The oligodendrocyte-type-2 astrocyte cell lineage is specialized for myelination

Charles ffrench-Constant
Martin C. Raff
Research25 Sept 1986
Nature

Volume: 323, P: 335-338
¹⁵N nuclear magnetic resonance of living cells

M. LLINÁS
K. WÜTHRICH
W. VON PHILIPSBORN
Research30 Oct 1975
Nature

Volume: 257, P: 817-818
Structure of a Mammalian Serine tRNA

M. STAEHELIN
H. ROGG
W. WEHRLI
Research28 Sept 1968
Nature

Volume: 219, P: 1363-1365
Is CO₂ responsible for the outbursts of comet Halley?

P. D. Feldman
M. F. A'Hearn
T. N. Woods
Research04 Dec 1986
Nature

Volume: 324, P: 433-436
Electronic states and phases of K_xC₆₀ from photoemission and X-ray absorption spectroscopy

C. T. Chen
L. H. Tjeng
E. W. Plummer
Research15 Aug 1991
Nature

Volume: 352, P: 603-605
Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain

Kiyoji Tanaka
Naoyuki Miura
Yoshio Okada
Research01 Nov 1990
Nature

Volume: 348, P: 73-76
Bipolarity of large anomalous Nernst effect in Weyl magnet-based alloy films

The key to enhance the output of a thermoelectric device is to be able to regulate the thermoelectric voltage generation. Topological magnet Co₃Sn₂S₂-based devices show the way to achieve that goal.

Shun Noguchi
Kohei Fujiwara
Atsushi Tsukazaki
Research08 Jan 2024
Nature Physics

Volume: 20, P: 254-260
Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509

Masato Iwatsuki
Ryuji Uchida
Satoshi Ōmura
Research01 Apr 2008
The Journal of Antibiotics

Volume: 61, P: 230-236
Discovery of orbital ordering in Bi₂Sr₂CaCu₂O_8+x

An orbitally ordered state in Bi₂Sr₂CaCu₂O_8+x is revealed, which splits the energy levels of oxygen orbitals by ~50 meV.

Shuqiu Wang
Niall Kennedy
Shane M. O’Mahony
ResearchOpen Access04 Mar 2024
Nature Materials

Volume: 23, P: 492-498
Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration

The extracellular matrix contributes to tissue regeneration by binding and releasing growth factors. Here the authors present the jigsaw-shaped self-assembling peptide JigSAP as an artificial ECM and show that VEGF-JigSAP has therapeutic effects on the subacute-chronic phase of brain stroke.

Atsuya Yaguchi
Mio Oshikawa
Itsuki Ajioka
ResearchOpen Access19 Nov 2021
Nature Communications

Volume: 12, P: 1-12
Reconstitution of microtubule into GTP-responsive nanocapsules

GTP-triggered release from drug carriers has huge potential in cancer therapy but current carriers suffers from off target release due to ATP also acting as a trigger. Here, the authors report on the development of a microtubule capsule which is engineered to be responsive to only GTP not ATP and demonstrate targeted drug delivery.

Noriyuki Uchida
Ai Kohata
Takuzo Aida
ResearchOpen Access15 Sept 2022
Nature Communications

Volume: 13, P: 1-11
Evolutionary conservation of H-Y (‘male’) antigen

STEPHEN S. WACHTEL
GLORIA C. KOO
EDWARD A. BOYSE
Research20 Mar 1975
Nature

Volume: 254, P: 270-272
Eemian cooling in the Norwegian Sea and North Atlantic ocean preceding continental ice-sheet growth

E. Cortijo
J. C. Duplessy
T. C. E. van Wearing
Research01 Dec 1994
Nature

Volume: 372, P: 446-449
Production of phenocopies by Krüppel antisense RNA injection into Drosophila embryos

Urs B. Rosenberg
Anette Preiss
Douglas C. Knipple
Research21 Feb 1985
Nature

Volume: 313, P: 703-706
Oxygen binding to haemoglobins of the primitive vertebrate Myxine glutinosa L.

C. BAUER
U. ENGELS
S. PALEUS
Research03 Jul 1975
Nature

Volume: 256, P: 66-68
Stable large variant of 5S RNA in Clostridium thermosaccharolyticum

L. A. SUTTON
C. R. WOESE
Research03 Jul 1975
Nature

Volume: 256, P: 64-66
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

Neural stem and progenitor cells (NSPCs) encounter constant stresses during aging, such as elevated oxidative stress. Here the authors show that oxidative stress induced reduction in NSPC neural differentiation is mediated by a FOXO3-GNMT/SAM-lamin-cGAS/STING-IFN-I signalling cascade initiated by FOXO3 oxidation.

Inah Hwang
Hiroki Uchida
Jihye Paik
ResearchOpen Access28 Jan 2021
Nature Communications

Volume: 12, P: 1-14
Solar burst with millimetre-wave emission at high frequency only

P. Kaufmann
E. Correia
B. R. Dennis
Research31 Jan 1985
Nature

Volume: 313, P: 380-382
Observation of triple J/ψ meson production in proton-proton collisions

The CMS Collaboration reports the study of three simultaneous hard interactions between quarks and gluons in proton–proton collisions. This manifests through the concurrent production of three J/ψ mesons, which consist of a charm-quark–antiquark pair.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access19 Jan 2023
Nature Physics

Volume: 19, P: 338-350
Stable isotope evidence for chemosynthesis in an abyssal seep community

C. K. Paull
A. J. T. Jull
T. Linick
Research24 Oct 1985
Nature

Volume: 317, P: 709-711
Controlled-source electromagnetic sounding of the oceanic lithosphere

C. S. Cox
S. C. Constable
S. C. Webb
Research06 Mar 1986
Nature

Volume: 320, P: 52-54
The wee1 protein kinase is required for radiation-induced mitotic delay

Roy Rowley
James Hudson
Paul G. Young
Research26 Mar 1992
Nature

Volume: 356, P: 353-355
Determination of the magnetic penetration depth of the high-T_c superconductor YBa₂Cu₃O_7–x by polarized neutron reflection

R. Felici
J. Penfold
C. Matacotta
Research08 Oct 1987
Nature

Volume: 329, P: 523-525
Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures

Removing immunogenic uncapped mRNA from transcribed mRNA can be challenging, but is critical in mRNA research and clinical applications such as vaccines. Here, authors develop hydrophobic photocaged tag-modified cap analogs, which can be used to separate capped mRNA from uncapped mRNA, with subsequent tag removal using photo-irradiation.

Masahito Inagaki
Naoko Abe
Hiroshi Abe
ResearchOpen Access11 May 2023
Nature Communications

Volume: 14, P: 1-17
A portrait of the Higgs boson by the CMS experiment ten years after the discovery

The most up-to-date combination of results on the properties of the Higgs boson is reported, which indicate that its properties are consistent with the standard model predictions, within the precision achieved to date.

A. Tumasyan
W. Adam
A. Zhokin
ResearchOpen Access04 Jul 2022
Nature

Volume: 607, P: 60-68
Measurements of pH versus drop size in natural rain

Stephen J. Adams
Stuart G. Bradley
Stephen J. de Mora
Research26 Jun 1986
Nature

Volume: 321, P: 842-844
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm

William C. Smith
Anne K. Knecht
Richard M. Harland
Research11 Feb 1993
Nature

Volume: 361, P: 547-549
Single organic monolayer imaging by electron microscopy

J. R. Fryer
R. A. Hann
B. L. Eyres
Research31 Jan 1985
Nature

Volume: 313, P: 382-384
Characterization of pertussis-like toxin from Salmonella spp. that catalyzes ADP-ribosylation of G proteins

Yukino Tamamura
Kiyoshi Tanaka
Ikuo Uchida
ResearchOpen Access01 Jun 2017
Scientific Reports

Volume: 7, P: 1-13
Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia

Ishikawa and colleagues perform integrated genomic and drug-sensitivity screens with extensive PDX modeling and reveal combined XIAP and BCL2 inhibition as a vulnerability hub across AML genetic alterations.

Mari Hashimoto
Yoriko Saito
Fumihiko Ishikawa
Research18 Mar 2021
Nature Cancer

Volume: 2, P: 340-356
Measurement of the Higgs boson width and evidence of its off-shell contributions to ZZ production

The CMS Collaboration reports evidence for off-shell Higgs boson contributions in the production of Z boson pairs, and measures the width of the Higgs boson, which is inversely related to its lifetime.

A. Tumasyan
W. Adam
W. Vetens
ResearchOpen Access20 Oct 2022
Nature Physics

Volume: 18, P: 1329-1334
Resonant Internal Wave Interactions

S. MARTIN
W. F. SIMMONS
C. I. WUNSCH
Research06 Dec 1969
Nature

Volume: 224, P: 1014-1016
An ordering transition in the turbulent flow of helium II

L. C. Krysac
G. M. Graham
Research08 Oct 1987
Nature

Volume: 329, P: 525-527
Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

Here the authors demonstrate that de novo DNA methylation mediated by DNMT3B is regulated by nitric oxide (NO). They also isolate a unique modulator (DBIC) that inhibits S-nitrosylation of DNMT3B, which mitigates cell proliferation and tumorigenic conversion in vivo.

Kosaku Okuda
Kengo Nakahara
Takashi Uehara
ResearchOpen Access04 Feb 2023
Nature Communications

Volume: 14, P: 1-16
Superconductivity at 23 K in yttrium palladium boride carbide

R. J. Cava
H. Takagi
S. Uchida
Research13 Jan 1994
Nature

Volume: 367, P: 146-148
Yaequinolones, New Insecticidal Antibiotics Produced by Penicillium sp. FKI-2140

Ryuji Uchida
Rie Imasato
Satoshi Ōmura
Research01 Oct 2006
The Journal of Antibiotics

Volume: 59, P: 652-658
Scattering interference signature of a pair density wave state in the cuprate pseudogap phase

The pseudogap phase in cuprate superconductors is predicted to be a pair density wave state (PDW) but experimental evidence has been lacking. Here, the authors detect the temperature evolution of energy gap modulations and scattering interference signature suggesting the Bi₂Sr₂CaDyCu₂O₈ pseudogap phase contains a PDW.

Shuqiu Wang
Peayush Choubey
J. C. Séamus Davis
ResearchOpen Access19 Oct 2021
Nature Communications

Volume: 12, P: 1-9

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