Nature Search

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

Anubha Mahajan
Min Jin Go
Andrew P Morris
Research09 Feb 2014
Nature Genetics

Volume: 46, P: 234-244
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Exome-sequencing analyses of a large cohort of patients with type 2 diabetes and control individuals without diabetes from five ancestries are used to identify gene-level associations of rare variants that are associated with type 2 diabetes.

Jason Flannick
Josep M. Mercader
Michael Boehnke
ResearchOpen Access22 May 2019
Nature

Volume: 570, P: 71-76
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

Yoon Shin Cho, Mark Seielstad and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes in individuals of east Asian ancestry. They identify eight new loci associated with type 2 diabetes.

Yoon Shin Cho
Chien-Hsiun Chen
Mark Seielstad
Research11 Dec 2011
Nature Genetics

Volume: 44, P: 67-72
Evidence for light-by-light scattering in heavy-ion collisions with the ATLAS detector at the LHC

Quantum electrodynamics predicts a rare process in which light is scattered by light. The ATLAS Collaboration reports signs of this elusive effect in the collisions of ultra-relativistic lead ions.

M. Aaboud
G. Aad
L. Zwalinski
ResearchOpen Access14 Aug 2017
Nature Physics

Volume: 13, P: 852-858
The genetic architecture of type 2 diabetes

Sequencing data from two large-scale studies show that most of the genetic variation influencing the risk of type 2 diabetes involves common alleles and is found in regions previously identified by genome-wide association studies, clarifying the genetic architecture of this disease.

Christian Fuchsberger
Jason Flannick
Mark I. McCarthy
Research11 Jul 2016
Nature

Volume: 536, P: 41-47
Electronic and atomic structures of the Sr₃Ir₄Sn₁₃ single crystal: A possible charge density wave material

H.-T. Wang
M. K. Srivastava
W.-F. Pong
ResearchOpen Access20 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.

Minako Imamura
Atsushi Takahashi
Takashi Kadowaki
ResearchOpen Access28 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Cannabinoid CB₂ receptor ligand profiling reveals biased signalling and off-target activity

CB₂ receptor agonists are developed as potential analgesics or immune-modulatory compounds. Here, the authors characterize the pharmacological properties of widely used CB₂ receptor agonists and antagonists, recommending three that appear most suitable for in vitro and in vivostudies.

Marjolein Soethoudt
Uwe Grether
Mario van der Stelt
ResearchOpen Access03 Jan 2017
Nature Communications

Volume: 8, P: 1-14
Measurement of the inelastic proton–proton cross-section at √s=7 TeV with the ATLAS detector

The measurement of the total cross-section of proton–proton collisions is of fundamental importance for particle physics. Here, the first measurement of the inelastic cross-section is presented for proton–proton collisions at an energy of 7 teraelectronvolts using the ATLAS detector at the Large Hadron Collider.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access06 Sept 2011
Nature Communications

Volume: 2, P: 1-14
Disordered array of Au covered Silicon nanowires for SERS biosensing combined with electrochemical detection

Annalisa Convertino
Valentina Mussi
Luca Maiolo
ResearchOpen Access26 Apr 2016
Scientific Reports

Volume: 6, P: 1-10
Androgen-related expression of G-proteins in ovarian cancer

L A Sheach
E M Adeney
R J Edmondson
ResearchOpen Access21 Jul 2009
British Journal of Cancer

Volume: 101, P: 498-503
Cardiovascular risk in the peritoneal dialysis patient

Cardiovascular disease is the most frequent cause of death in patients on peritoneal dialysis. In this Review, Krediet and Balafa describe cardiovascular risk factors that may affect the general population, those that are related to end-stage renal disease, and those that are specific to patients on peritoneal dialysis. The authors also discuss how these factors may be modified by changes in residual kidney function and/or peritoneal dialysis.

Raymond T. Krediet
Olga Balafa
Reviews22 Jun 2010
Nature Reviews Nephrology

Volume: 6, P: 451-460
Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion

D Li
R R Hodges
D A Dartt
Research06 Mar 2013
Mucosal Immunology

Volume: 6, P: 1119-1130
Increase in stroke risk in patients with head and neck cancer: a retrospective cohort study

C-N Chu
S-W Chen
F-C Sung
ResearchOpen Access13 Sept 2011
British Journal of Cancer

Volume: 105, P: 1419-1423
Sindbis virus replicon particles encoding calreticulin linked to a tumor antigen generate long-term tumor-specific immunity

W-F Cheng
C-N Lee
C-A Chen
Research28 Apr 2006
Cancer Gene Therapy

Volume: 13, P: 873-885
Kirsten ras mutations in patients with colorectal cancer: the ‘RASCAL II’ study

H J N Andreyev
A R Norman
N Urosevic
ResearchOpen Access28 Aug 2001
British Journal of Cancer

Volume: 85, P: 692-696
Regulation of the tyrosine kinase substrate Eps8 expression by growth factors, v-Src and terminal differentiation

Rita Gallo
Claudia Provenzano
Stefano Alemà
Research16 Oct 1997
Oncogene

Volume: 15, P: 1929-1936
A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress

Q Huang
Y-T Wu
H-M Shen
Research31 Oct 2008
Cell Death & Differentiation

Volume: 16, P: 264-277
Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia

D-C Liang
C-P Yang
K-S Lin
Research17 Dec 2009
Leukemia

Volume: 24, P: 397-405
Using multiple cytokines to predict hepatocellular carcinoma recurrence in two patient cohorts

Z-Y Chen
W Wei
R-P Guo
ResearchOpen Access17 Dec 2013
British Journal of Cancer

Volume: 110, P: 733-740
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Jason Flannick
Christian Fuchsberger
Mark I. McCarthy
Amendments and CorrectionsOpen Access23 Jan 2018
Scientific Data

Volume: 5, P: 1-2
CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells

C Delehouzé
K Godl
L Meijer
Research09 Dec 2013
Oncogene

Volume: 33, P: 5675-5687
PPARγ is essential for protection against nonalcoholic steatohepatitis

C W Wu
E S H Chu
J Yu
Research08 Apr 2010
Gene Therapy

Volume: 17, P: 790-798
WW domain-containing oxidoreductase promotes neuronal differentiation via negative regulation of glycogen synthase kinase 3β

H-Y Wang
L-I Juo
P-J Lu
ResearchOpen Access23 Dec 2011
Cell Death & Differentiation

Volume: 19, P: 1049-1059
Connective tissue growth factor linked to the E7 tumor antigen generates potent antitumor immune responses mediated by an antiapoptotic mechanism

W-F Cheng
M-C Chang
C-A Chen
Research20 Mar 2008
Gene Therapy

Volume: 15, P: 1007-1016
Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78

H-Y Tsai
Y-F Yang
M Hsiao
Research14 Jan 2013
Oncogene

Volume: 32, P: 4921-4931

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