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Showing 1–7 of 7 results
Advanced filters: Author: C-ting Wu Clear advanced filters

  • Imaging technologies drive discovery in cell biology. Innovations in microscopy hardware, imaging methods and computational analysis of large-scale, complex datasets can increase imaging resolution, definition and allow access to new biology. We asked experts at the leading edge of biological imaging what they are most excited about when it comes to microscopy in cell biology and what challenges need to be overcome to reach these goals.

    • Brenda Andrews
    • Jae-Byum Chang
    • Assaf Zaritsky
    Reviews
    Nature Cell Biology
    Volume: 24, P: 1180-1185

  • This technique, adapted from mosaic analysis with double markers in mice, relies on mitotic recombination to reconstitute sequences encoding EGFP or mRFP1. After cell division, each daughter cell contains one fluorescent marker, causing a green and a red twin spot that can be traced through development.

    • Ruth Griffin
    • Anne Sustar
    • Norbert Perrimon
    Research
    Nature Methods
    Volume: 6, P: 600-602

  • Homologs are paired in Drosophila somatic cells from embryogenesis to adulthood. Using a computational approach for haplotype-resolved Hi-C, the authors reveal highly structured homolog pairing in Drosophila embryos during zygotic genome activation and demonstrate its application to mammalian embryos.

    • Jelena Erceg
    • Jumana AlHaj Abed
    • C.-ting Wu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • OligoFISSEQ combines Oligopaints with fluorescence in situ sequencing to enable the 3D mapping of many regions across the genome in human cells to interrogate genome organization at improved genomic resolution. OligoFISSEQ is compatible with immunochemistry and OligoSTORM for super-resolution imaging.

    • Huy Q. Nguyen
    • Shyamtanu Chattoraj
    • C.-ting Wu
    Research
    Nature Methods
    Volume: 17, P: 822-832

  • Trans-homolog interactions, such as homolog pairing, are highly structured and associated with gene function in Drosophila cells. Here, the authors use haplotype-resolved Hi-C to identify genome-wide trans-homolog interactions in a Drosophila hybrid cell line and investigate their patterns and functional roles.

    • Jumana AlHaj Abed
    • Jelena Erceg
    • C.-ting Wu
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Shamil Sunyaev, Alexander Gimelbrant and colleagues report an analysis of the genetic variability in human monoallelically expressed genes. They find that genes with monoallelic expression show greater genetic diversity than biallelically expressed genes and that this diversity is associated with greater allelic age.

    • Virginia Savova
    • Sung Chun
    • Alexander A Gimelbrant
    Research
    Nature Genetics
    Volume: 48, P: 231-237