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Showing 1–5 of 5 results
Advanced filters: Author: C. H. Reijmer Clear advanced filters
  • Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts, whereby mutant p53-expressing cancer cells activate an exosome-mediated mechanism that influences integrin recycling in fibroblasts, thus influencing extracellular matrix remodelling to favour cancer cell invasion and migration.

    • David Novo
    • Nikki Heath
    • Jim C. Norman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17
  • Svalbard glaciers are among the lowest ice masses in the Arctic, with a peak in glacier area below 450 m elevation. Using a high-resolution climate model, here the authors show that a modest warming in the mid-1980s propagated meltwater runoff above the glacier area peak, amplifying Svalbard mass loss from all elevations.

    • Brice Noël
    • C. L. Jakobs
    • M. R. van den Broeke
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8
  • Argon and luminescence dating of fossil shell infills from Trinil in Java, where Homo erectus lived, reveals that the hominin-bearing deposits are younger than previously thought; perforated shells, a shell tool and an engraved shell indicate that Homo erectus ate freshwater mussels, used their shells as tools and was able to create abstract engravings.

    • Josephine C. A. Joordens
    • Francesco d’Errico
    • Wil Roebroeks
    Research
    Nature
    Volume: 518, P: 228-231