Nature Search

Measuring fast stochastic displacements of bio-membranes with dynamic optical displacement spectroscopy

Precise quantification of stochastic motions of biological membranes is limited by a lack of suitable detection methods. Here Monzelet al. develop dynamic optical displacement spectroscopy to measure stochastic membrane displacements at 20 nm/10 μs spatiotemporal resolution.

C. Monzel
D. Schmidt
R. Merkel
ResearchOpen Access06 Oct 2015
Nature Communications

Volume: 6, P: 1-8
Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids

Generation of a midbrain-striatum assembloid with progerin overexpression as an in vitro model of possessing aging and senescence characteristics for studying Parkinson’s disease.

Kyriaki Barmpa
Claudia Saraiva
Jens C. Schwamborn
ResearchOpen Access23 Nov 2024
Communications Biology

Volume: 7, P: 1-19
Deciphering shared molecular dysregulation across Parkinson’s disease variants using a multi-modal network-based data integration and analysis

Alise Zagare
Irina Balaur
Jens C. Schwamborn
ResearchOpen Access31 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-14
Omics data integration suggests a potential idiopathic Parkinson’s disease signature

Transcriptomics and metabolomics data integration coupled with systems biology reveal signature differences in idiopathic Parkinson’s disease vs healthy controls, with pyruvate, amino acid, lipid and NAD metabolism as most dysregulated pathways.

Alise Zagare
German Preciat
Jens C. Schwamborn
ResearchOpen Access20 Nov 2023
Communications Biology

Volume: 6, P: 1-14
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases

A meta-analysis of 17 cohorts of mitochondrial disease patients reveals that OxPhos defects are associated with signs of hypermetabolism. Experiments in patient-derived fibroblast show that mitochondrial OxPhos defects trigger hypermetabolism in a cell-autonomous manner and this is linked to accelerated telomere shortening and epigenetic aging.

Gabriel Sturm
Kalpita R. Karan
Martin Picard
ResearchOpen Access12 Jan 2023
Communications Biology

Volume: 6, P: 1-22
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids

Isabel Rosety
Alise Zagare
Jens C. Schwamborn
ResearchOpen Access18 Dec 2023
npj Parkinson's Disease

Volume: 9, P: 1-16
Modeling Parkinson’s disease in midbrain-like organoids

Lisa M. Smits
Lydia Reinhardt
Jens C. Schwamborn
ResearchOpen Access05 Apr 2019
npj Parkinson's Disease

Volume: 5, P: 1-8
Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress

M Shatirishvili
A S Burk
V Orian-Rousseau
ResearchOpen Access10 Nov 2016
Cell Death & Disease

Volume: 7, P: e2461

Search

Filter By:

Search

Quick links