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Showing 1–5 of 5 results
Advanced filters: Author: C. Rulten Clear advanced filters
  • Chromosomal single-strand DNA breaks occur frequently and require repair to avoid disease outcomes. Here, the authors show that in bird cells, PARP3 accelerates this repair, and use structural biology and cell biology techniques to reveal details of the mechanism of action.

    • Gabrielle J. Grundy
    • Luis M. Polo
    • Keith W. Caldecott
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12
  • Aprataxin cleans up unfinished DNA ligation intermediates. By cleaving off an adenylate group at the site of a ligatable nick, aprataxin generates ends that can then be re-ligated. This suggests that neurodegeneration results from the accumulation of these intermediates in post-mitotic neuronal cells.

    • Ivan Ahel
    • Ulrich Rass
    • Stephen C. West
    Research
    Nature
    Volume: 443, P: 713-716
  • Deep γ-ray observations of the Galactic Centre with arcminute angular resolution show traces of petaelectronvolt protons within the central ten parsecs of our Galaxy; the accelerator of these particles could have provided a substantial contribution to Galactic cosmic rays in the past.

    • A. Abramowski
    • F. Aharonian
    • HESS Collaboration
    Research
    Nature
    Volume: 531, P: 476-479