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cellSTAAR advances noncoding rare variant association analysis by integrating single-cell genomics data.

Scholl et al. show that PopZ forms filamentous condensates driven by its helical domain and inhibited by its disordered region. Phase-dependent conformations modulate client interactions and disruption of filamentation or condensation impairs cellular function and growth.

Mass-wasting deposits that accumulated against mid-ocean ridge faults have high porosity in which calcium carbonate precipitated, storing seawater carbon dioxide, as revealed by cores of a 61-million-year-old seafloor talus deposit.

Here the authors use Ramsey interferometry to study Tan’s contact in uniform two-dimensional Bose gas of 87Rb atoms across the Berezinskii–Kosterlitz–Thouless superfluid transition. They find that the two-body contact is continuous across the critical point.

Nylon-11 is a common and durable polymer but possess low piezoelectric properties. Here, the authors use mechanical accelerations and strong electric fields to induce crystallization, hydrogen-bonding and dipole alignment in Nylon-11 films, achieving high piezoelectricity.

Oxytocin promotes social behaviors, but its cortical targets remain unclear. Here, authors show that oxytocin activates local interneurons in the rat prefrontal cortex, enhancing sociability through top-down control of the basolateral amygdala.

Tan and colleagues present “cycling molecular assemblies” that borrow cellular lipidation machinery to build nanostructures inside the Golgi apparatus. These tools enable rapid organelle imaging and selective destruction of cancer cells.

ALMA has captured exquisitely detailed images of bowshock shells in the outflow of an outbursting protostar. These provide important insights into the variable nature of the ejections from protostars, which play a key role in star and planet formation.

The genetic basis underlying resistance to Sclerotinia stem rot (SSR) in oilseed rape remains elusive. Here, the authors identify BnaA07.MKK9 as a pivotal regulator of SSR resistance in oilseed rape by GWAS, providing new insights into plant defense mechanisms against necrotrophic pathogens.

Chromosomes are coated in proteins and RNA called the mitotic chromosome periphery. Here, broadband microrheology analysis has shown that this coat has dynamic, liquid-like properties and provides an external structural constraint.

Tanycytic insulin receptors allow insulin access to the hypothalamic arcuate nucleus and are relevant for driving AgRP neuronal activity in response to feeding.

Adaptive microwave surfaces can dynamically adjust their electromagnetic transmission to meet specific needs, being potentially useful in reconfigurable communication systems. Here, the authors use temperature induced break and reconstruction of hydrogen bonds to drive the orientational motion and charge mobility of an ionic liquid in a polymer leading to the controllable modulation of dielectric properties at microwave frequencies.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

The Yamaji effect is a modulation of the electronic transport as the angle of an applied magnetic field is changed. This has been observed in a model cuprate and sheds light on the geometry of the Fermi surface and the nature of the pseudogap.

A M5 earthquake triggered the 2018 Sierra Negra eruption after 10 hours. Subsequent microseismicity revealed a cryptic fluid phase facilitated magma intrusion, highlighting that cascading processes are potentially essential for eruption initiations.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

In vivo base editing of a causative mutation that leads to the neurodevelopmental disorder Snijders Blok–Campeau syndrome restores protein dosage and ameliorates molecular and behavioural deficits in a humanized mouse model of the condition.

Findings from a tectonically active mountain range show that soil production is driven by bottom-up rock weakening rather than by soil thickness, challenging long-held top-down models.

Vortex dynamics and mutual friction in quantum fluids are intimately connected to the fundamental properties of superfluids. Here, the authors reveal previously unexplored mechanisms underlying the mutual friction coefficients in ultracold Fermi superfluids in the unitary limit, suggesting bound quasiparticles within the vortex core play a significant role.

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Droplet impacts shape technologies from erosion to bioprinting. Here, authors show a scaling crossover in peak impact force on soft substrates, from inertial to Hertzian, unified by a similarity parameter. The proposed stress tomography provides a practical map to design impact-resistant processes.

Genome-wide association meta-analysis identifies 58 independent risk loci for major anxiety disorders among individuals of European ancestry and implicates GABAergic signaling as a potential mechanism underlying genetic risk for these disorders.

NatD is an acetyltransferase responsible for N-α-terminal acetylation of the histone H4 and H2A and has been linked to cell growth. Here the authors show that NatD-mediated acetylation of histone H4 serine 1 competes with the phosphorylation by CK2α at the same residue thus leading to the upregulation of Slug and tumor progression.

We present a sustainably sourced adhesive system, with performance comparable to that of current industrial products, made from epoxidized soy oil, malic acid and tannic acid, all biomass derived, low cost and readily available.

Nitrogen-rich Ruddlesden–Popper nitrides are notoriously difficult to stabilize. Now a high-pressure high-temperature synthesis method has enabled the preparation of Pr₂ReN₄, Nd₂ReN₄ and Ce₂TaN₄. Neutron diffraction analysis reveals fully nitrided materials and intricate magnetic structures.

This work highlights how changes to beaches are related to sand movement and human impacts to the coast and illuminates opportunities for sand management to resolve shoreline erosion and enhance beach sustainability.

This scoping review examines previous experience in performing silent evaluations of clinical AI applications, collecting evidence from 75 studies on implementation features and the sociotechnical context.

MARSIS attenuation and thermal data confirm that liquid brines are the most plausible source for the bright reflections at the base of the South Polar Layered Deposits. Such results also justify why SHARAD does not penetrate to the base of the ice.

Bacterial biofilms include viscous extracellular polymeric matrices such as extracellular DNA (eDNA). Here, Mugunthan et al. show that protein RecA generates three-stranded nucleic acid structures known as R-loops, which contribute to formation of the viscoelastic eDNA matrix as part of bacterial stress responses.

Theoretical and experimental analysis of the effect of grain shape in bed load sediment transport is performed and a shape-corrected sediment transport law that provides greater accuracy in predictions is proposed.

The authors report an experimental study of the Hall effect measuring electrical quantities in ultracold fermionic quantum simulators. This provides a way forward in measuring transport properties in these platforms and verifying long-standing theoretical predictions.

Dimorphos ejecta plume properties were revealed by the observations from the LICIACube cube satellite, which was deployed 15  days in advance of the impact of DART.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

Gravitational lens modelling of a million-solar-mass dark object reveals that it cannot be a free-floating black hole or dark-matter halo as predicted by cold dark matter, instead indicating a peculiar and highly concentrated mass distribution.

Combining gas permeability and self-adaptive compliance in breathable, on-skin electronics is challenging. Here, the authors overcome this by using coaxial electrospinning to create an ionic nanomesh which encapsulates a self-compliant liquid crystal elastomer core within a permeable ionic sheath.

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinoma and that Smad3 targeting reprograms TANs to an antitumor state suppressing tumor growth in preclinical lung cancer models.

Here the authors show a general method to make alkoxide-based network-forming glasses with tunable properties by combining titanium, zirconium and boron-based nodes, multi-dentate alcohol linkers and mono-dentate alcohol modulators.

Recovering nitrate from surface water can help address interconnected environmental, resource, and energy challenges. A bioinspired photothermal evaporation platform enabling the co-recovery of low-concentration nitrate and freshwater is proposed.

Conventional lithography methods involve the transfer of patterns through resist templating. Here, the authors explore a concept based on the Moiré interference of molecular beams to directly write complex 3D surfaces and self-aligned superlattices.

Macrocyclization typically proceeds via thioesterase mediation in type I polyketide synthases. Now, using genome mining and crystallographic analysis, an alternative mechanism for stereoselective macrocyclization in the akaeolide biosynthetic pathway is reported. The mechanism is proposed to proceed via an iminium-catalysed tandem Michael addition and Knoevenagel condensation, using nuclear transport factor 2-like enzymes.

Rathmell and colleagues show that metabolic reprograming of regulatory T cells is associated with severity of critical illness in patients with and without sepsis.

Cavity-mediated interactions lead to collective effects and ordering in ultracold atomic systems. Here, the authors demonstrate the interplay of different ordered states of ultracold Fermi gases in a cavity, resulting from an intriguing coexistence of photon coupling with both atoms and atom-pairs.

Spatial transcriptomics (ST) technologies link tissue morphology with gene expression, but remain expensive to use; furthermore, models that predict ST data from histopathology images possess considerable limitations. Here, the authors develop STimage, a deep learning probabilistic framework for ST prediction from histopathology images while prioritising robustness and interpretability.

High-pressure measurements of the electrical conductivity of (Mg,Fe)O, used as an analogue for basal magma ocean material, indicate that the conductivity is high enough to produce a dynamo much stronger than a core-driven dynamo for super-Earths larger than 3–6 Earth masses.