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Showing 1–50 of 63 results

Advanced filters: Author: C. Thomas Caskey Clear advanced filters

Release Factor Translation of RNA Phage Terminator Codons

ARTHUR L. BEAUDET
C. THOMAS CASKEY
Research04 Jul 1970
Nature

Volume: 227, P: 38-40
Expression of peptide chain release factor 2 requires high-efficiency frameshift

William J. Craigen
C. Thomas Caskey
Research17 Jul 1986
Nature

Volume: 322, P: 273-275
Safe gene vectors made simpler

Manal A. Morsy
C. Thomas Caskey
Research01 Jan 1997
Nature Biotechnology

Volume: 15, P: 17
A missense mutation in the dystrophin gene in a Duchenne muscular dystrophy patient

Thomas W. Prior
Audrey C. Papp
Jerry R. Mendell
Research01 Aug 1993
Nature Genetics

Volume: 4, P: 357-360
Initiator Codons in Eukaryotes

J. C. BROWN
A. E. SMITH
Research16 May 1970
Nature

Volume: 226, P: 610-612
Molecular evidence for new mutation at the hprt locus in Lesch-Nyhan patients

Thomas P. Yang
Pragna I. Patel
C. Thomas Caskey
Research02 Aug 1984
Nature

Volume: 310, P: 412-414
Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand

T. Hünig
G. Tiefenthaler
S. C. Meuer
Research25 Mar 1987
Nature

Volume: 326, P: 298-301
Non-Darwinian Evolution: A Critique

ROLLIN C. RICHMOND
Research14 Mar 1970
Nature

Volume: 225, P: 1025-1028
PCR test for cystic fibrosis deletion

ANDREA BALLABIO
RICHARDA. GIBBS
C. THOMAS CASKEY
Research18 Jan 1990
Nature

Volume: 343, P: 220
Hypermutable myotonic dystrophy CTG repeats in transgenic mice

Darren G. Monckton
Mary I. Coolbaugh
C. Thomas Caskey
Research01 Feb 1997
Nature Genetics

Volume: 15, P: 193-196
Alterations of the hprt gene in human in vivo-derived 6-thioguanine-resistant T lymphocytes

Richard J. Albertini
J. Patrick O'Neill
Philip C. Kelleher
Research25 Jul 1985
Nature

Volume: 316, P: 369-371
Expression of recombinant dystrophin and its localization to the cell membrane

Cheng Chi Lee
Joel A. Pearlman
C. Thomas Caskey
Research24 Jan 1991
Nature

Volume: 349, P: 334-336
Carbon Compounds in Apollo 11 Lunar Samples

BARTHOLOMEW NAGY
WARD M. SCOTT
HAROLD C. UREY
Research14 Mar 1970
Nature

Volume: 225, P: 1028-1032
Lateral diffusion of rhodopsin in the photoreceptor membrane

Mu-ming Poo
Richard A. Cone
Research15 Feb 1974
Nature

Volume: 247, P: 438-441
Genetics: New aid to human gene mapping

C. Thomas Caskey
News & Views07 Mar 1985
Nature

Volume: 314, P: 19
Instability of short tandem repeats (microsatellites) in human cancers

R. Wooster
A.-M. Cleton-Jansen
M.R. Stratton
Research01 Feb 1994
Nature Genetics

Volume: 6, P: 152-156
Expression of human HPRT in the central nervous system of transgenic mice

J. Timothy Stout
Howard Y. Chen
Ralph L. Brinster
Research19 Sept 1985
Nature

Volume: 317, P: 250-252
Expression of human adenosine deaminase in murine haematopoietic progenitor cells following retroviral transfer

John W. Belmont
Jenny Henkel-Tigges
C. Thomas Caskey
Research24 Jul 1986
Nature

Volume: 322, P: 385-387
Isolation of a Miller–Dicker lissencephaly gene containing G protein β-subunit-like repeats

Orly Reiner
Romeo Carrozzo
David H. Ledbetter
Research19 Aug 1993
Nature

Volume: 364, P: 717-721
A hybrid recognition sequence in a recombinant restriction enzyme and the evolution of DNA sequence specificity

Valakunja Nagaraja
John C. W. Shepherd
Thomas A. Bickle
Research25 Jul 1985
Nature

Volume: 316, P: 371-372
Effect of Thrombin, Adenosine Diphosphate, Connective Tissue, and Endotoxin on Platelet Glycolysis

MILTON CORN
Research29 Oct 1966
Nature

Volume: 212, P: 508
An Oxo-bridged Five-coordinate Iron(III) Molecule

M. GERLOCH
E. D. MCKENZIE
A. D. C. TOWL
Research30 Nov 1968
Nature

Volume: 220, P: 906-907
Convergent antibody responses to SARS-CoV-2 in convalescent individuals

Although rare, antibodies against the receptor-binding domain of SARS-CoV-2 that showed potent antiviral activity were obtained from all tested convalescent individuals, suggesting that a vaccine designed to elicit such antibodies could be broadly effective.

Davide F. Robbiani
Christian Gaebler
Michel C. Nussenzweig
Research18 Jun 2020
Nature

Volume: 584, P: 437-442
N-Acetylglucosamine-6-Sulfate Sulfatase in Man: Deficiency of the Enzyme in a New Mucopolysaccharidosis

Leonard C Ginsberg
Patricia V Donnelly
C Thomas Caskey
Research01 Jul 1978
Pediatric Research

Volume: 12, P: 805-809
A physically altered leucyl-tRNA synthetase complex in a CHO cell mutant

ARNOLD E. HAMPEL
PRESTON O. RITTER
M. DUANE ENGER
Research01 Dec 1978
Nature

Volume: 276, P: 844-845
Leptin receptor missense mutation in the fatty Zucker rat

Michael S. Phillips
Qingyun Liu
J. Fred Hess
Correspondence01 May 1996
Nature Genetics

Volume: 13, P: 18-19
HUGO and gene patents

C. Thomas Caskey
Correspondence01 Jun 1995
Nature

Volume: 375, P: 351
Evolution of antibody immunity to SARS-CoV-2

In a cohort of 87 individuals with COVID-19, the memory B cell response at 6.2 months after the onset of disease evolves in a manner that is consistent with the persistence of SARS-CoV-2 antigen.

Christian Gaebler
Zijun Wang
Michel C. Nussenzweig
Research18 Jan 2021
Nature

Volume: 591, P: 639-644
Merck, SmithKline and patents

C. Thomas Caskey
Alan R. Williamson
Correspondence30 May 1996
Nature

Volume: 381, P: 360
Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

Klaas Kok
Jan Osinga
Charles H. C. M. Buys
Research10 Dec 1987
Nature

Volume: 330, P: 578-581
Molecular genetic approaches to the analysis of human ophthalmic disease

David N Cooper
Marcelle Jay
Barrie Jay
Research01 Nov 1987
Eye

Volume: 1, P: 699-721
Evidence for a Function for the UAA Codon in vivo

GEORGE J. KANTOR
STANLEY PERSON
F. ALAN ANDERSEN
Research02 Aug 1969
Nature

Volume: 223, P: 535-537
Safety and antiviral activity of triple combination broadly neutralizing monoclonal antibody therapy against HIV-1: a phase 1 clinical trial

A combination of three monoclonal antibodies transiently reduced viremia in people living with HIV-1 and not on antiretroviral therapy, but it did not prevent viral rebound. Further studies are needed to determine if this approach can be optimized.

Boris Julg
Kathryn E. Stephenson
Dan H. Barouch
ResearchOpen Access12 May 2022
Nature Medicine

Volume: 28, P: 1288-1296
Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites

Amalio Telenti, Craig Venter and colleagues report common, low-frequency and rare variants associated with blood metabolite levels using whole-genome sequencing and comprehensive metabolite profiling in 1,960 individuals. They identify 246 metabolites whose levels are associated with genetic variation at 101 loci.

Tao Long
Michael Hicks
Amalio Telenti
Research06 Mar 2017
Nature Genetics

Volume: 49, P: 568-578
Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial

Coupling cure interventions with ART during early HIV infection may accelerate virus clearance and enhance T cell responses, supporting tailoring of monoclonal antibodies to sensitive viruses to improve their effects.

Jesper D. Gunst
Marie H. Pahus
Ole S. Søgaard
Research17 Oct 2022
Nature Medicine

Volume: 28, P: 2424-2435
Identification of receptors for neuromedin U and its role in feeding

Andrew D. Howard
Ruiping Wang
Qingyun Liu
Research06 Jul 2000
Nature

Volume: 406, P: 70-74
Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Combination therapy with the anti-HIV-1 monoclonal antibodies 3BNC117 and 10-1074 maintains long-term suppression in the absence of antiretroviral therapy in individuals with antibody-sensitive viral reservoirs.

Pilar Mendoza
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature

Volume: 561, P: 479-484
Correction: Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Marina Caskey
Florian Klein
Michel C. Nussenzweig
Amendments and Corrections23 Mar 2016
Nature

Volume: 535, P: 580
Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial

In people with HIV-1 undergoing antiretroviral treatment interruption, lefitolimod combined with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.

Jesper D. Gunst
Jesper F. Højen
Ole S. Søgaard
ResearchOpen Access11 Sept 2023
Nature Medicine

Volume: 29, P: 2547-2558
Characterization of the human cysteinyl leukotriene CysLT₁ receptor

Kevin R. Lynch
Gary P. O'Neill
Jilly F. Evans
Research24 Jun 1999
Nature

Volume: 399, P: 789-793
Marshall Nirenberg (1927–2010)

A humble, gentle and visionary giant of molecular biology.

C. Thomas Caskey
News & Views03 Mar 2010
Nature

Volume: 464, P: 44
Truncating mutations of MAGEL2 cause Prader-Willi phenotypes and autism

Christian Schaaf, Manuel Gonzalez-Garay and colleagues report the identification of four individuals with truncating mutations on the paternal allele of MAGEL2, a gene within the imprinted domain linked to Prader-Willi syndrome (PWS). The four individuals have PWS or PWS-related phenotypes, and all have autism.

Christian P Schaaf
Manuel L Gonzalez-Garay
Yaping Yang
Research29 Sept 2013
Nature Genetics

Volume: 45, P: 1405-1408
Marshall Nirenberg

Errol C. Friedberg
Research Highlights01 Mar 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 190-191
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8⁺ T cell immunity

Broadly neutralising anti-HIV-1 antibody (bNAb) administration in nonhuman primates has been shown to stimulate adaptive T cell-specific immunity, with infection prevention observed. In this work, the authors longitudinally analyse HIV-1 specific cellular immunity in HIV-1- infected individuals starting ART with or without adjunctive bNAb treatment.

Miriam Rosás-Umbert
Jesper D. Gunst
Ole S. Søgaard
ResearchOpen Access29 Oct 2022
Nature Communications

Volume: 13, P: 1-12
A gene expression microarray database for drug metabolism and toxicology

David Gerhold
Jian Xu
Tom Rushmore
Research Highlights01 Nov 1999
Nature Genetics

Volume: 23, P: 46
Antibody 10-1074 suppresses viremia in HIV-1-infected individuals

Florian Klein and colleagues report that treating viremic HIV-1-infected individuals with the broadly neutralizing antibody 10-1074 reduced virus levels in blood, but antibody-resistant virus did emerge.

Marina Caskey
Till Schoofs
Florian Klein
Research16 Jan 2017
Nature Medicine

Volume: 23, P: 185-191
Identification of the gene responsible for Best macular dystrophy

Konstantin Petrukhin
Markus J. Koisti
Claes Wadelius
Research01 Jul 1998
Nature Genetics

Volume: 19, P: 241-247
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

A phase I study of passive immunization with a CD4 binding-site-directed broadly neutralizing antibody shows that it transiently reduces HIV-1 viral loads in humans.

Marina Caskey
Florian Klein
Michel C. Nussenzweig
Research08 Apr 2015
Nature

Volume: 522, P: 487-491
Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy

Mutations in glycyl-tRNA synthetase (GlyRS) cause Charcot-Marie-Tooth disease, a neuromuscular disorder characterized by axonal degeneration. Here the authors show that mutant GlyRS interacts with histone deacetylase 6, resulting in increased deacetylation of α-tubulin and axonal transport deficits.

Zhongying Mo
Xiaobei Zhao
Xiang-Lei Yang
ResearchOpen Access08 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals

Combination of two broadly neutralizing antibodies is effective in reducing HIV-1 viremia and in limiting the emergence of resistant viral variants in individuals harboring antibody-sensitive viruses.

Yotam Bar-On
Henning Gruell
Michel C. Nussenzweig
Research26 Sept 2018
Nature Medicine

Volume: 24, P: 1701-1707

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