In this study, the authors show that neural correlates of insight, including synaptic efficacy in the orbitofrontal cortex (OFC), are lost in rodents which are allowed to self-administer cocaine, suggesting a link between drug use and adaptation to changing circumstances. Optogenetic activation of OFC pyramidal neurons was able to rescue these behaviors.
- Federica Lucantonio
- Yuji K Takahashi
- Geoffrey Schoenbaum