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Advanced filters: Author: Cagdas Tazearslan Clear advanced filters

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

The authors show that the neuron-specific LSD1 variant (LSD1n) promotes transcription initiation and elongation in response to neuronal activity. LSD1n is essential for spatial learning and long-term memory formation. LSD1n exhibits novel substrate specificity for histone H4 K20 methylation.

Jianxun Wang
Francesca Telese
Michael G Rosenfeld
Research27 Jul 2015
Nature Neuroscience

Volume: 18, P: 1256-1264
Clinical and analytical validation of a combined RNA and DNA exome assay across a large tumor cohort

Yudina et al. present clinical validation guidelines for an integrated RNA and DNA sequencing assay. Applied to over 2000 tumors, the assay enhances precision oncology by capturing complex variants missed by DNA-only testing.

Anastasiya Yudina
Cagdas Tazearslan
Alexander Bagaev
ResearchOpen Access16 Jun 2025
Communications Medicine

Volume: 5, P: 1-21
Procrustes is a machine-learning approach that removes cross-platform batch effects from clinical RNA sequencing data

Procrustes is a machine-learning algorithm that can overcome batch effects across RNA-seq data obtained by different sample preparation methods, like exome capture-based or poly-A RNA-seq protocols.

Nikita Kotlov
Kirill Shaposhnikov
Alexander Bagaev
ResearchOpen Access30 Mar 2024
Communications Biology

Volume: 7, P: 1-14

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