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Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia

Shilatifard and colleagues demonstrate gain-of-function mutations in ASXL1 that drive BAP1 stabilization and widespread epigenetic changes in myeloid neoplasms, and develop a chemical inhibitor with therapeutic potential for ASXL1-altered leukemia.

Lu Wang
Noah Warren Birch
Ali Shilatifard
Research25 May 2021
Nature Cancer

Volume: 2, P: 515-526
Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

A CRISPR screen for MLL2-dependent transcription identifies a compensatory repressive mechanism involving PRC2 and DNA methylation. PRC2 inactivation or DNA demethylation activates gene expression in the absence of H3K4me3.

Delphine Douillet
Christie C. Sze
Ali Shilatifard
Research11 May 2020
Nature Genetics

Volume: 52, P: 615-625

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Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

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