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Showing 1–4 of 4 results

Advanced filters: Author: Caitriona Holohan Clear advanced filters

Cancer drug resistance: an evolving paradigm

This Review discusses mechanisms of resistance to 'classical' cytotoxic chemotherapeutics and molecularly targeted therapies, which share many features. It is hoped that an improved understanding of the molecular basis of resistance will lead to rational drug combinations and predictive biomarkers.

Caitriona Holohan
Sandra Van Schaeybroeck
Patrick G. Johnston
Reviews24 Sept 2013
Nature Reviews Cancer

Volume: 13, P: 714-726
Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

Jennifer Ferris
Margarita Espona-Fiedler
Victoria Coyle
ResearchOpen Access21 Jul 2020
Cell Death Discovery

Volume: 6, P: 1-14
The SCF^Skp2 ubiquitin ligase complex modulates TRAIL-R2-induced apoptosis by regulating FLIP(L)

Jamie Z. Roberts
Caitriona Holohan
Daniel B. Longley
ResearchOpen Access20 Apr 2020
Cell Death & Differentiation

Volume: 27, P: 2726-2741
Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

Christopher McCann
Nyree Crawford
Daniel B. Longley
ResearchOpen Access22 Oct 2018
Cell Death & Disease

Volume: 9, P: 1-13