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Showing 1–25 of 25 results
Advanced filters: Author: Caleb Shi Clear advanced filters

  • Lung adenocarcinomas bearing the ID2 mutational signature display increased LINE-1 retrotransposon activity, which contributes to their fast evolutionary dynamics and aggressive phenotype.

    • Tongwu Zhang
    • Wei Zhao
    • Maria Teresa Landi
    Research
    Nature
    Volume: 650, P: 230-241

  • An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

    • Marcos Díaz-Gay
    • Tongwu Zhang
    • Maria Teresa Landi
    Research
    Nature
    Volume: 644, P: 133-144

  • A survey of the cellular RNA-binding proteins (RBPs) that interact with dengue virus and Zika virus genomic RNA identifies ribosome-binding protein 1 and vigilin as bona fide RBPs able to promote viral RNA translation, replication and stability.

    • Yaw Shin Ooi
    • Karim Majzoub
    • Jan E. Carette
    Research
    Nature Microbiology
    Volume: 4, P: 2369-2382

  • Mouse models often combine mutant alleles to accelerate cancer development, limiting oncogenic diversity. Here the authors show that sporadic MYC activation in Vk*MYC mice is sufficient to induce tumors with a variety of secondary mutations that mirror the genetic heterogeneity of human myeloma.

    • Francesco Maura
    • David G. Coffey
    • Marta Chesi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a potential modulator binding site in the PHF5A–SF3B1 complex.

    • Teng Teng
    • Jennifer HC Tsai
    • Ping Zhu
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Radio pulses from a rare, radio-loud magnetar, XTE J1810−197, are seen to have undergone a conversion in their polarization state. This change can be linked to the magnetar’s magnetic field geometry, and has commonalities with an effect also seen in fast radio bursts.

    • Marcus E. Lower
    • Simon Johnston
    • Benjamin W. Stappers
    ResearchOpen Access
    Nature Astronomy
    Volume: 8, P: 606-616

  • Self-driving laboratories promise accelerated discovery. As the scope of chemical processes and level of autonomy in these laboratories expand, a comprehensive safety framework is essential. We discuss here the safety development trajectory of SDLs, identifying opportunities for innovation to shape this rapidly evolving landscape.

    • Shi Xuan Leong
    • Caleb E. Griesbach
    • Alán Aspuru-Guzik
    Reviews
    Nature Reviews Chemistry
    Volume: 9, P: 707-722

  • Flexible materials for harvesting and storing energy are desirable for wearable electronics, but efficiency is still an issue. Here, the authors demonstrate a flexible and weavable ribbon which integrates a solar cell and supercapacitor via a shared electrode for efficient energy harvesting and storage.

    • Chao Li
    • Md. Monirul Islam
    • Jayan Thomas
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • The results of the Fifth RNA-Puzzles contest highlights advances in RNA three-dimensional structure prediction and uncovers new insights into RNA folding and structure.

    • Fan Bu
    • Yagoub Adam
    • Zhichao Miao
    ResearchOpen Access
    Nature Methods
    Volume: 22, P: 399-411

  • The genome of the grey short-tailed opossum Monodelphis domestica has been sequenced and analyzed, giving a first peek at a marsupial's genetic code. Of particular interest are the genetics of the immune system, which has been studied as a model for humans, and of the X chromosome for historical reasons.

    • Tarjei S. Mikkelsen
    • Matthew J. Wakefield
    • Kerstin Lindblad-Toh
    Research
    Nature
    Volume: 447, P: 167-177

  • Immune analyses against circulating SARS-CoV-2 variants show that mRNA vaccination induces robust neutralizing antibodies and boosts cross-variant neutralizing antibodies elicited by SARS-CoV-2 infection.

    • Carolina Lucas
    • Chantal B. F. Vogels
    • Akiko Iwasaki
    Research
    Nature
    Volume: 600, P: 523-529

  • The Cancer Genome Atlas Research Network reports an integrative analysis of more than 400 samples of clear cell renal cell carcinoma based on genomic, DNA methylation, RNA and proteomic characterisation; frequent mutations were identified in the PI(3)K/AKT pathway, suggesting this pathway might be a potential therapeutic target, among the findings is also a demonstration of metabolic remodelling which correlates with tumour stage and severity.

    • Chad J. Creighton
    • Margaret Morgan
    • Heidi J. Sofia.
    ResearchOpen Access
    Nature
    Volume: 499, P: 43-49

  • The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

    • Jesse M. Engreitz
    • Heather A. Lawson
    • Ella K. Samer
    Reviews
    Nature
    Volume: 633, P: 47-57

  • Single-atom-thick graphene sheets can be produced at metre scales, bringing large-area applications in electronics and photovoltaics closer. However, such large pieces can be expected to be polycrystalline, so that it is important to determine the nature and size of grains in large-area graphene. This paper uses a combination of old and new transmission electron microscope techniques to carry out atomic-resolution imaging at grain boundaries as well as mapping of the location, orientation and shape of several hundred grains and boundaries with diffraction-filtered imaging. By correlating grain imaging with scanned probe and transport measurements, it is shown that the grain boundaries dramatically weaken the mechanical strength of graphene membranes, but do not as dramatically alter their electrical properties.

    • Pinshane Y. Huang
    • Carlos S. Ruiz-Vargas
    • David A. Muller
    Research
    Nature
    Volume: 469, P: 389-392

  • Current clinical practice is organized according to tissue or organ of origin of tumors. Now, The Cancer Genome Atlas (TCGA) Research Network has started to identify genomic and other molecular commonalities among a dozen different types of cancer. Emerging similarities and contrasts will form the basis for targeted therapies of the future and for repurposing existing therapies by molecular rather than histological similarities of the diseases.

    • Kyle Chang
    • Chad J Creighton
    • Joshua M Stuart
    Comments & OpinionOpen Access
    Nature Genetics
    Volume: 45, P: 1113-1120