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Showing 1–9 of 9 results
Advanced filters: Author: Caleb Stein Clear advanced filters

  • Multiple myeloma (MM) cancer cells can develop different resistance mechanisms to therapies inducing DNA-damage. Here, the authors show that the mitochondrial DNA repair protein DNA2 promotes MM cells survival after DNA damage-induced metabolic reprogramming.

    • Natthakan Thongon
    • Feiyang Ma
    • Simona Colla
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Mouse models often combine mutant alleles to accelerate cancer development, limiting oncogenic diversity. Here the authors show that sporadic MYC activation in Vk*MYC mice is sufficient to induce tumors with a variety of secondary mutations that mirror the genetic heterogeneity of human myeloma.

    • Francesco Maura
    • David G. Coffey
    • Marta Chesi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • A new Burden of Proof meta-analytic method that accounts for between-study heterogeneity and corrects for bias between different study designs is used to interpret the strength of evidence between different pairs of risk factors and health outcomes.

    • Peng Zheng
    • Ashkan Afshin
    • Christopher J. L. Murray
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 2038-2044

  • The autistic spectrum disorders (ASDs) are highly heritable, yet the underlying genetic determinants remain largely unknown. Here, a genome-wide analysis of rare copy number variants (CNVs) has been carried out, revealing that ASD sufferers carry a higher load of rare, genic CNVs than do controls. Many of these CNVs are de novo and inherited. The results implicate several novel genes in ASDs, and point to the importance of cellular proliferation, projection and motility, as well as specific signalling pathways, in these disorders.

    • Dalila Pinto
    • Alistair T. Pagnamenta
    • Catalina Betancur
    Research
    Nature
    Volume: 466, P: 368-372

  • Arteriovenous malformations are characterized by a direct link between arteries and veins without intervening capillaries. This Primer highlights high rupture and haemorrhage risk when these occur in the brain, as well as the diagnosis and management options available to patients.

    • Michael T. Lawton
    • W. Caleb Rutledge
    • Robert F. Spetzler
    Reviews
    Nature Reviews Disease Primers
    Volume: 1, P: 1-20