A mouse lymphoma model that shows a similar level of genomic instability generally seen in human cancer has been created. In a comparative genomics approach, recurrent genetic alterations found in this model are used as a filter to identify overlapping alterations in human T-cell acute lymphoblastic lymphomas, including in the FBXW7 and NOTCH genes.
- Richard S. Maser
- Bhudipa Choudhury
- Ronald A. DePinho
