Nature Search

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

Nicholas Luscombe, Cameron Osborne and colleagues report the use of Capture Hi-C (CHi-C) to detect the long-range interactions of almost 22,000 promoters in 2 human cell types. They found that transcriptionally inactive genes interact with previously uncharacterized elements that may act as long-range silencers.

Borbala Mifsud
Filipe Tavares-Cadete
Cameron S Osborne
Research04 May 2015
Nature Genetics

Volume: 47, P: 598-606
Artificial reef footprint in the United States ocean

Artificial reefs provide important ecosystem services in marine environments. Accurate knowledge of the area covered by such reefs can help evaluate benefits and risks of such structures. This study describes the physical footprint of artificial reefs deployed in coastal waters of the United States.

Avery B. Paxton
D’amy N. Steward
J. Christopher Taylor
Research18 Jan 2024
Nature Sustainability

Volume: 7, P: 140-147
Dopamine D1 receptors facilitate transmitter release

Donald L. Cameron
John T. Williams
Research25 Dec 1993
Nature

Volume: 366, P: 344-347
In vivo Bubble Detection by Acoustic–Optical Imaging Techniques

RICHARD G. BUCKLES
CAMERON KNOX
Research24 May 1969
Nature

Volume: 222, P: 771-772
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Identification of long-term survivors in primary breast cancer by dynamic modelling of tumour response

D A Cameron
W M Gregory
R C F Leonard
ResearchOpen Access06 Jun 2000
British Journal of Cancer

Volume: 83, P: 98-103
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

The PML-RARA gene fusion is the characteristic driver of Acute Promyelocytic Leukaemia (APL) and is known to bind to the genome. Here, the authors characterise the impact of PML-RARA on gene regulation in APL cell lines and patient samples using transcriptomics, epigenomics, and machine learning.

William Villiers
Audrey Kelly
Cameron S. Osborne
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-17
A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067

Observations of six transiting planets around the bright nearby star HD 110067 show that they follow a chain of resonant orbits, with three of the planets inferring the presence of large hydrogen-dominated atmospheres.

R. Luque
H. P. Osborn
T. Zingales
Research29 Nov 2023
Nature

Volume: 623, P: 932-937
Long-range chromatin regulatory interactions in vivo

David Carter
Lyubomira Chakalova
Peter Fraser
Research11 Nov 2002
Nature Genetics

Volume: 32, P: 623-626
Replication and transcription: Shaping the landscape of the genome

Lyubomira Chakalova
Emmanuel Debrand
Peter Fraser
Reviews10 Aug 2005
Nature Reviews Genetics

Volume: 6, P: 669-677
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression

Mice bearing mutations in Flt3-ITD and Npm1c, which are commonly found in acute myeloid leukemia, are used to characterize the cooperative effects of these cancer drivers on the cellular epigenome and three-dimensional genome conformation during tumor development.

Haiyang Yun
Nisha Narayan
Brian J. P. Huntly
Research23 Sept 2021
Nature Genetics

Volume: 53, P: 1443-1455
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Active genes dynamically colocalize to shared sites of ongoing transcription

Cameron S Osborne
Lyubomira Chakalova
Peter Fraser
Research07 Sept 2004
Nature Genetics

Volume: 36, P: 1065-1071
Comprehensive genomic characterization defines human glioblastoma genes and core pathways

With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

Roger McLendon
Allan Friedman
Elizabeth Thomson
Research04 Sept 2008
Nature

Volume: 455, P: 1061-1068
Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer

Promoter capture Hi-C in colorectal cancer cells integrated with cancer genome and expression data identifies a noncoding, cis-regulatory element that is recurrently mutated in cancer, affecting ETV1 expression, cell viability and patient survival.

Giulia Orlando
Philip J. Law
Richard S. Houlston
Research17 Sept 2018
Nature Genetics

Volume: 50, P: 1375-1380
Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome

Sarah Elderkin and colleagues show that PRC1 acts as a master regulator of genome architecture in mouse embryonic stem cells by organizing genes in three-dimensional interaction networks. They find that the strongest spatial network is composed of the four Hox clusters and key early developmental transcription factor genes, and they propose that selective release of genes from this spatial network underlies cell fate specification during embryonic development.

Stefan Schoenfelder
Robert Sugar
Sarah Elderkin
Research31 Aug 2015
Nature Genetics

Volume: 47, P: 1179-1186
A prognostic index for operable, node-negative breast cancer

M McCallum
C Baker
M Steel
ResearchOpen Access27 Apr 2004
British Journal of Cancer

Volume: 90, P: 1933-1941
A new family of periplasmic-binding proteins that sense arsenic oxyanions

Consuelo Badilla
Thomas H. Osborne
Joanne M. Santini
ResearchOpen Access19 Apr 2018
Scientific Reports

Volume: 8, P: 1-12
Evaluation of potential reference genes in the biting midge Culicoides sonorensis for real-time quantitative PCR analyses

Cameron Osborne
Anastasia M. W. Cooper
Kristopher Silver
ResearchOpen Access04 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Single-agent paclitaxel in patients with previously untreated stage IV epithelial ovarian cancer

ME Gore
G Rustin
JM Thompson
Research01 Mar 1997
British Journal of Cancer

Volume: 75, P: 710-714
Economic evaluation of fulvestrant as an extra step in the treatment sequence for ER-positive advanced breast cancer

D A Cameron
D R Camidge
M Hirsch
ResearchOpen Access18 Nov 2008
British Journal of Cancer

Volume: 99, P: 1984-1990

Search

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

Artificial reef footprint in the United States ocean

Dopamine D1 receptors facilitate transmitter release

In vivo Bubble Detection by Acoustic–Optical Imaging Techniques

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Identification of long-term survivors in primary breast cancer by dynamic modelling of tumour response

Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia

A resonant sextuplet of sub-Neptunes transiting the bright star HD 110067

Long-range chromatin regulatory interactions in vivo

Replication and transcription: Shaping the landscape of the genome

Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Active genes dynamically colocalize to shared sites of ongoing transcription

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer

Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome

A prognostic index for operable, node-negative breast cancer

A new family of periplasmic-binding proteins that sense arsenic oxyanions

Evaluation of potential reference genes in the biting midge Culicoides sonorensis for real-time quantitative PCR analyses

Single-agent paclitaxel in patients with previously untreated stage IV epithelial ovarian cancer

Economic evaluation of fulvestrant as an extra step in the treatment sequence for ER-positive advanced breast cancer

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