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Showing 1–3 of 3 results
Advanced filters: Author: Camilla Calandrini Clear advanced filters

  • Paediatric kidney tumours comprise many different subtypes, each being heterogeneous in their cellular as well as genetic composition. Advances in the past decade in 3D culture models create new opportunities for the generation of preclinical models capturing this phenotypic and genetic heterogeneity, potentially enabling the generation of patient-tailored therapies.

    • Ariadne H. A. G. Ooms
    • Camilla Calandrini
    • Jarno Drost
    Comments & Opinion
    Nature Reviews Urology
    Volume: 17, P: 311-313

  • Pre-clinical cell culture models capturing the heterogeneity of childhood kidney tumours are limited. Here, the authors establish and characterise an organoid biobank of tumour and matched normal organoid cultures from over 50 children with different subtypes of kidney cancer.

    • Camilla Calandrini
    • Frans Schutgens
    • Jarno Drost
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • Malignant rhabdoid tumours (MRT) have been suggested to originate in the ectoderm-derived neural crest. Here, the authors analyse MRTs using phylogenetics, scRNA-seq, and patient-derived organoids; they find evidence for an MRT origin in the neural crest lineage and suggest differentiation treatment with HDAC/mTOR inhibitors.

    • Lars Custers
    • Eleonora Khabirova
    • Jarno Drost
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11