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Showing 1–4 of 4 results

Advanced filters: Author: Cara-lin Lonetree Clear advanced filters

Author Correction: Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Beau R. Webber
Cara-lin Lonetree
Branden S. Moriarity
Amendments and CorrectionsOpen Access06 Dec 2019
Nature Communications

Volume: 10, P: 1
Highly efficient multiplex human T cell engineering without double-strand breaks using Cas9 base editors

Multiplexed genome engineering with Cas9 can increase efficiency but also the risk of unintended alterations. Here the authors demonstrate the use of multiplexed base editors on primary T cells with reduced translocation frequency.

Beau R. Webber
Cara-lin Lonetree
Branden S. Moriarity
ResearchOpen Access19 Nov 2019
Nature Communications

Volume: 10, P: 1-10
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells

Base editors can inactivate splice sites or introduce stop codons into a gene sequence. Here the authors present SpliceR to design, rank, and test sgRNAs for efficient gene disruption in T cells.

Mitchell G. Kluesner
Walker S. Lahr
Branden S. Moriarity
ResearchOpen Access23 Apr 2021
Nature Communications

Volume: 12, P: 1-12
CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa

Beau R Webber
Mark J Osborn
Jakub Tolar
ResearchOpen Access08 Dec 2016
npj Regenerative Medicine

Volume: 1, P: 1-11