Nature Search

siRNA-directed inhibition of HIV-1 infection

Carl D. Novina
Michael F. Murray
Phillip A. Sharp
Research03 Jun 2002
Nature Medicine

Volume: 8, P: 681-686
Author Correction: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

Rebekka K Schneider
Monica Schenone
Benjamin L Ebert
Amendments and Corrections23 Oct 2024
Nature Medicine

Volume: 30, P: 3382
Erratum: The microRNA miR-31 inhibits CD8⁺ T cell function in chronic viral infection

Howell F Moffett
Adam N R Cartwright
Kai W Wucherpfennig
Amendments and Corrections19 Sept 2017
Nature Immunology

Volume: 18, P: 1173
Erratum: siRNA-directed inhibition of HIV-1 infection

Carl D Novina
Michael F Murray
Phillip A Sharp
Amendments and Corrections01 Nov 2003
Nature Medicine

Volume: 9, P: 1433
Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins

Argonaute family members are effectors in small RNA-mediated silencing. In vitro analysis of the four human Argonautes demonstrates that AGO1 and AGO2 mediate multiple rounds of microRNA strand dissociation, mediate siRNA passenger-strand cleavage activity, and indicate distinct mechanisms from mRNA endonuclease activity.

Bingbing Wang
Shuqiang Li
Carl D Novina
Research29 Nov 2009
Nature Structural & Molecular Biology

Volume: 16, P: 1259-1266
Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9

In a mouse model of the 5q- subtype of myelodysplastic syndrome, haploinsufficiency of the ribosomal protein gene Rps14 leads to anemia through a mechanism involving innate immune signaling and the Tlr4 ligand S100A8, which induces a p53-dependent block to erythroid differentiation.

Rebekka K Schneider
Monica Schenone
Benjamin L Ebert
Research15 Feb 2016
Nature Medicine

Volume: 22, P: 288-297
On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

A vascularized human bone-marrow-on-a-chip improves the maintenance of patient-derived CD34⁺ cells, and recapitulates clinically relevant aspects of bone marrow injury as well as key haematopoietic defects of patients with a rare genetic disorder.

David B. Chou
Viktoras Frismantas
Donald E. Ingber
Research27 Jan 2020
Nature Biomedical Engineering

Volume: 4, P: 394-406
The microRNA miR-31 inhibits CD8⁺ T cell function in chronic viral infection

Wucherpfennig and colleagues show that the microRNA miR-31 increases the sensitivity of T cells to type I interferons, which interferes with effector T cell function during chronic infection.

Howell F Moffett
Adam N R Cartwright
Kai W Wucherpfennig
Research22 May 2017
Nature Immunology

Volume: 18, P: 791-799
Author Correction: On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

David B. Chou
Viktoras Frismantas
Donald E. Ingber
Amendments and Corrections12 Feb 2020
Nature Biomedical Engineering

Volume: 4, P: 477
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A

Zusen Fan
Paul J. Beresford
Judy Lieberman
Research13 Jan 2003
Nature Immunology

Volume: 4, P: 145-153
Killing the messenger: short RNAs that silence gene expression

Derek M. Dykxhoorn
Carl D. Novina
Phillip A. Sharp
Reviews01 Jun 2003
Nature Reviews Molecular Cell Biology

Volume: 4, P: 457-467
The RNAi revolution

The term RNAi — short for RNA interference — crops up again and again in biology research these days. This is in part because of its power as a laboratory tool, and in part because it is a widespread natural phenomenon.

Carl D. Novina
Phillip A. Sharp
News & Views08 Jul 2004
Nature

Volume: 430, P: 161-164
Targeted DNA methylation in human cells using engineered dCas9-methyltransferases

Tina Xiong
Glenna E. Meister
Carl D. Novina
ResearchOpen Access27 Jul 2017
Scientific Reports

Volume: 7, P: 1-14
AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Abraham Heifets
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
Author Correction: AI is a viable alternative to high throughput screening: a 318-target study

Izhar Wallach
Denzil Bernard
Ellie Giles
Amendments and CorrectionsOpen Access16 Sept 2024
Scientific Reports

Volume: 14, P: 1-2

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