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Showing 1–11 of 11 results
Advanced filters: Author: Carla Taveggia Clear advanced filters
  • Treatments for myelin disorders, such as multiple sclerosis, are largely confined to anti-inflammatory drugs, which often show limited effectiveness in only subgroups of patients. Combination therapies that target both inflammation and other processes, such as remyelination, might be of benefit in such disorders. In this article, Taveggia et al. provide an overview of the signaling pathways that regulate myelination and highlight how targeting such pathways might promote remyelination.

    • Carla Taveggia
    • Maria Laura Feltri
    • Lawrence Wrabetz
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 276-287
  • A new study shows that, immediately after axon injury, glycolysis is increased in Schwann cells to provide axons with energy and prevent them from degenerating. The authors also identify possible therapeutic targets that could be modulated to promote axonal protection.

    • Amelia Trimarco
    • Carla Taveggia
    News & Views
    Nature Neuroscience
    Volume: 23, P: 1179-1181
  • Neuregulin 1 (NRG1) type III is a key mediator of Schwann cell development and myelination and is known to undergo proteolytic cleavage to produce an intracellular fragment. In this study, the authors show that this intracellular fragment of NRG1 modulates myelination by inducing the expression of a prostaglandin synthase (L-PGDS) which, in turn, leads to prostaglandin production and activation of GPR44.

    • Amelia Trimarco
    • Maria Grazia Forese
    • Carla Taveggia
    Research
    Nature Neuroscience
    Volume: 17, P: 1682-1692
  • The authors report that TACE, the tumor necrosis factor-α–converting enzyme, regulates PNS myelination by affecting neuregulin-1 type III activity. Mice lacking TACE in motor neurons show hypermyelination.

    • Rosa La Marca
    • Federica Cerri
    • Carla Taveggia
    Research
    Nature Neuroscience
    Volume: 14, P: 857-865
  • Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory reprogramming of neighboring tumour cells leading to disease progression and poor prognosis for patients.

    • Nicoletta Caronni
    • Federica La Terza
    • Renato Ostuni
    Research
    Nature
    Volume: 623, P: 415-422
  • Schwann cells (SCs) myelinate peripheral nerve axons and offer opportunities for the treatment of injuries and demyelinating diseases but reliable and renewable sources of these cells are hard to come by. Here the authors reprogram rat, mouse and human fibroblasts into Schwann cells using two transcription factors.

    • Pietro Giuseppe Mazzara
    • Luca Massimino
    • Vania Broccoli
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13
  • The neurotrophic cytokine leukaemia inhibitory factor (LIF) prevents oligodendrocyte death in animal models of multiple sclerosis. Here, Laterza et al. show that secretion of LIF from transplanted iPSC-derived neural progenitor cells has a therapeutic effect in a mouse model of multiple sclerosis.

    • Cecilia Laterza
    • Arianna Merlini
    • Gianvito Martino
    Research
    Nature Communications
    Volume: 4, P: 1-16
  • The alternative splicing factor Nova2 is best known for its pivotal function in the brain. Giampietro et al. reveal an important role for Nova2 in the regulation of alternative splicing of transcripts in the vascular endothelium that are crucial for the maintenance of endothelial cell polarity and vessel lumen formation in zebrafish.

    • Costanza Giampietro
    • Gianluca Deflorian
    • Claudia Ghigna
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15
  • A recent paper in Science reports that for Schwann cells to initiate myelination, the Par-3 polarity protein must interact with the neurotrophin receptor p75NTR and relocate it to membrane domains of glia-axon contact.

    • Carla Taveggia
    • James L Salzer
    News & Views
    Nature Neuroscience
    Volume: 10, P: 17-18