The authors expose Xenopus tadpoles to the convulsant PTZ. After an initial PTZ exposure, seizure onset times were delayed in response to a second PTZ exposure. This protective effect resulted from conversion of putrescine into GABA, which in turn activated GABAB receptors presynaptically and altered the balance of inhibition to excitation.
- Mark R Bell
- James A Belarde
- Carlos D Aizenman
