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Showing 1–2 of 2 results
Advanced filters: Author: Carlos García-Echeverría Clear advanced filters

  • Inhibitors of PI3 kinase are in development for the treatment of cancer. But whether these compounds will work as single agents remains to be seen. Engelman et al. now show that a PI3K-mTOR inhibitor is effective in a mouse model of lung cancer induced by a mutant PIK3CA but has no effect on Kras-induced tumors. Combining the PI3K-mTOR inhibitor with a MEK inhibitor induced regression of mouse Kras tumors, suggesting that such combinations may be beneficial in human tumors (pages 1315–1316).

    • Jeffrey A Engelman
    • Liang Chen
    • Kwok-Kin Wong
    Research
    Nature Medicine
    Volume: 14, P: 1351-1356

  • The complex of Grb2-SH2 a BCR-Abl target peptide reveals that the peptide binds in a β-turn conformation; Trp 121 closes the binding site C-terminal to the phosphotyrosyl residue of the ligand and prevents it from assuming the expected extended conformation.

    • Joseph Rahuel
    • Brigitte Gay
    • Markus G. Grütter
    Correspondence
    Nature Structural Biology
    Volume: 3, P: 586-589