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Showing 1–3 of 3 results
Advanced filters: Author: Carlos Labão-Almeida Clear advanced filters

  • STING is a promising drug target, but selective activation is necessary for safety and efficacy. Researchers have developed a two-component prodrug system for potent pharmacological activation of STING that offers excellent tumour targeting.

    • Nai-Shu Hsu
    • Cong Tang
    • Gonçalo J. L. Bernardes
    ResearchOpen Access
    Nature Chemistry
    P: 1-11

  • A hyper-stable de novo protein mimic of interleukin-2 computationally designed to not interact with a regulatory T-cell specific receptor subunit has improved therapeutic activity in mouse models of melanoma and colon cancer.

    • Daniel-Adriano Silva
    • Shawn Yu
    • David Baker
    Research
    Nature
    Volume: 565, P: 186-191