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Showing 1–6 of 6 results
Advanced filters: Author: Carole L. Linster Clear advanced filters

  • CLYBL has a role beyond itaconate catabolism to degrade malyl-CoA, a noncanonical metabolite and methylmalonyl-CoA mutase inhibitor that depletes coenzyme B12, implying that malyl-CoA contributes to the B12 deficiency observed in individuals with CLYBL loss of function.

    • Corey M. Griffith
    • Jean-François Conrotte
    • Carole L. Linster
    Research
    Nature Chemical Biology
    Volume: 21, P: 906-915

  • Attenuating effects of the ketogenic diet on colorectal cancer (CRC) cell growth has been previously described. Here, using a mouse model of CRC with a humanized microbiome, the authors identify a shift toward gut bacterial species that produce stearic acid in ketogenic conditions, resulting in elevated levels of free stearate in the gut lumen, which they then show exhibits tumor-suppressing properties.

    • Mina Tsenkova
    • Madita Brauer
    • Elisabeth Letellier
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • The glycolytic enzymes GAPDH and pyruvate kinase produce 4-phosphoerythronate and 2-phospho-L-lactate, which block metabolic flux. A newly identified conserved metabolic repair enzyme, phosphoglycolate phosphatase, eliminates these side products.

    • François Collard
    • Francesca Baldin
    • Guido T Bommer
    Research
    Nature Chemical Biology
    Volume: 12, P: 601-607

  • Metabolites and cofactors can be converted to unwanted compounds by promiscuous enzymes and spontaneous chemical reactions. The growing list of enzymes that correct or prevent these reactions, akin to those that combat DNA and protein damage, have important roles in maintaining homeostasis and preventing disease.

    • Carole L Linster
    • Emile Van Schaftingen
    • Andrew D Hanson
    Reviews
    Nature Chemical Biology
    Volume: 9, P: 72-80