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Showing 1–3 of 3 results
Advanced filters: Author: Carole Pennetier Clear advanced filters
  • It is unclear why certain tissues are more susceptible to the consequences of aneuploidy. Here, in Drosophila, Gogendeau et al.identify aneuploidy as the cause of lengthened G1 and premature differentiation in both neural and adult intestinal stem cells, which prevents cells with abnormal genomes from cycling.

    • Delphine Gogendeau
    • Katarzyna Siudeja
    • Renata Basto
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15
  • Centrosome amplification is often seen in cancer cells and may cause aneuploidy. Basto and colleagues unexpectedly find that centrosome amplification (induced by Plk4 overexpression) in the mouse central nervous system causes microcephaly due to depletion of the neural stem cell pool through aneuploidy and cell death.

    • Véronique Marthiens
    • Maria A. Rujano
    • Renata Basto
    Research
    Nature Cell Biology
    Volume: 15, P: 731-740
  • The microcephaly protein ASPM is required for correct spindle positioning in neuroepithelial cells. Basto and colleagues demonstrate that, in addition to having a role in cell division, the fly ASPM orthologue Asp is important for the maintenance of neuroepithelium integrity by mediating myosin II apico-basal polarity.

    • Maria A. Rujano
    • Luis Sanchez-Pulido
    • Renata Basto
    Research
    Nature Cell Biology
    Volume: 15, P: 1294-1306