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Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

There are many patients who do not respond to immune checkpoint inhibitor (ICI) immunotherapy. Here, the authors show a significant negative correlation between sphingosine kinase-1 (SK1) expression and survival for ICI-treated melanoma patients, and further show that targeting SK1 improves response to ICI in mouse cancer models.

Caroline Imbert
Anne Montfort
Céline Colacios
ResearchOpen Access23 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Minors at risk of von Hippel-Lindau disease: 10 years’ experience of predictive genetic testing and follow-up adherence

Roseline Vibert
Khadija Lahlou-Laforêt
Anne-Paule Gimenez-Roqueplo
Research02 Aug 2022
European Journal of Human Genetics

Volume: 30, P: 1171-1177
TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells.

Florie Bertrand
Anne Montfort
Bruno Ségui
ResearchOpen Access22 Dec 2017
Nature Communications

Volume: 8, P: 1-13
CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress

Jérémy Sitbon
Dennis Nestvogel
Stéphane Jamain
Research15 Feb 2022
Molecular Psychiatry

Volume: 27, P: 1145-1157
Time-resolved single-cell RNA-seq using metabolic RNA labelling

The combination of single-cell RNA sequencing with metabolic RNA labelling enables a time-resolved view of transcriptional responses in individual cells. In this Primer, Erhard and Saliba et al. discuss metabolic labelling approaches and how to assess the temporal dynamics of transcriptional responses in different conditions.

Florian Erhard
Antoine-Emmanuel Saliba
Lars Dölken
Reviews29 Sept 2022
Nature Reviews Methods Primers

Volume: 2, P: 1-18
Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel–Lindau gene in the ccRCC

Franck Chesnel
Emmanuelle Jullion
Yannick Arlot-Bonnemains
Research29 Sept 2022
British Journal of Cancer

Volume: 127, P: 1954-1962
Landscape of pathogenic variations in a panel of 34 genes and cancer risk estimation from 5131 HBOC families

Laurent Castéra
Valentin Harter
Dominique Vaur
Research10 Jul 2018
Genetics in Medicine

Volume: 20, P: 1677-1686
Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Lisa Golmard
Laurent Castéra
Claude Houdayer
Research08 Nov 2017
European Journal of Human Genetics

Volume: 25, P: 1345-1353
Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

Stéphanie Baert-Desurmont
Françoise Charbonnier
Thierry Frebourg
ResearchOpen Access15 Apr 2015
European Journal of Human Genetics

Volume: 24, P: 99-105
Otopalatodigital spectrum disorders: refinement of the phenotypic and mutational spectrum

Sébastien Moutton
Patricia Fergelot
Isabelle Coupry
Research19 May 2016
Journal of Human Genetics

Volume: 61, P: 693-699

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Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Minors at risk of von Hippel-Lindau disease: 10 years’ experience of predictive genetic testing and follow-up adherence

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress

Time-resolved single-cell RNA-seq using metabolic RNA labelling

Mutation of the proline P81 into a serine modifies the tumour suppressor function of the von Hippel–Lindau gene in the ccRCC

Landscape of pathogenic variations in a panel of 34 genes and cancer risk estimation from 5131 HBOC families

Contribution of germline deleterious variants in the RAD51 paralogs to breast and ovarian cancers

Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

Otopalatodigital spectrum disorders: refinement of the phenotypic and mutational spectrum

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