Nature Search

Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Extracting high-order cosmological information in galaxy surveys with power spectra

Baryon Acoustic Oscillations (BAO) are formed in the early universe and can be measured galaxy redshift survey to probe dark energy, but this feature is degraded with galaxy structure evolution. The authors propose a method that simultaneously use pre- and post-reconstruction power spectra to extract higher order information for surveys to constrain cosmological models.

Yuting Wang
Gong-Bo Zhao
Fei Ge
ResearchOpen Access18 Apr 2024
Communications Physics

Volume: 7, P: 1-9
Getting a grip on iron

Siderocalin (also known as lipocalin 2) is a component of the innate immune system that binds and sequesters bacterial iron compounds in the blood and urine. A new study identifies iron–catechol complexes as endogenous ligands for siderocalin, which can deliver the iron compounds to the kidney.

Caroline Philpott
News & Views01 Aug 2010
Nature Chemical Biology

Volume: 6, P: 568-570
Plastic debris in lakes and reservoirs

Analysis of plastic debris found in surface waters shows that lakes and reservoirs in densely populated and urbanized regions, as well as those with elevated deposition areas, are particularly vulnerable to plastic contamination.

Veronica Nava
Sudeep Chandra
Barbara Leoni
Research12 Jul 2023
Nature

Volume: 619, P: 317-322
Estimating internationally imported cases during the early COVID-19 pandemic

Sparse testing early in the SARS-CoV-2 pandemic hinders estimation of the dates and origins of initial case importations. Here, the authors show that the main source of cases imported from China shifted from Wuhan to other Chinese cities by mid-February, especially for African locations.

Tigist F. Menkir
Taylor Chin
Rene Niehus
ResearchOpen Access12 Jan 2021
Nature Communications

Volume: 12, P: 1-10
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Andrew Morris, Mark McCarthy, Michael Boehnke and colleagues report a meta-analysis of genome-wide association studies for type 2 diabetes, including 26,488 cases and 83,964 controls from populations of European, east Asian, south Asian and Mexican and Mexican American ancestry. They identify seven loci newly associated with type 2 diabetes and examine the genetic architecture of disease across populations.

Anubha Mahajan
Min Jin Go
Andrew P Morris
Research09 Feb 2014
Nature Genetics

Volume: 46, P: 234-244
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

Erik L. Bao
Satish K. Nandakumar
Vijay G. Sankaran
Research14 Oct 2020
Nature

Volume: 586, P: 769-775
Associations of autozygosity with a broad range of human phenotypes

Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

David W Clark
Yukinori Okada
James F Wilson
ResearchOpen Access31 Oct 2019
Nature Communications

Volume: 10, P: 1-17
APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

The APOE4 allele is a major genetic risk factor for the development of late-onset Alzheimer’s disease (AD). In this manuscript, Butovsky and colleagues suggest that APOE4 impairs the microglial response in AD by inducing TGFβ-mediated checkpoints.

Zhuoran Yin
Neta Rosenzweig
Oleg Butovsky
Research25 Sept 2023
Nature Immunology

Volume: 24, P: 1839-1853
Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn’s disease

Crohn’s disease (CD) is a complex disease associated with immune dysregulation. Here the authors use multimodal data to identify and characterize an epithelial cell population, termed ‘LND’ cells, in both terminal ileum and ascending colon, with LND interacting locally with immune cells and potentially contributing to CD pathology.

Jia Li
Alan J. Simmons
Qi Liu
ResearchOpen Access22 Aug 2024
Nature Communications

Volume: 15, P: 1-19
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Gene discovery and polygenic predictions from a genome-wide association study of educational attainment in 1.1 million individuals.

James J. Lee
Robbee Wedow
David Cesarini
Research23 Jul 2018
Nature Genetics

Volume: 50, P: 1112-1121
Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma

Rpn13 is a substrate receptor of the 26S proteasome and an anti-cancer drug target. Here, the authors identify and characterize XL5, a lead compound that binds to the N-terminal Pru domain of human Rpn13 (hRpn13), solve the NMR structure of XL5-ligated hRpn13 Pru and develop XL5-PROTACs that preferentially target an identified hRpn13 Pru fragment present in multiple myeloma cells.

Xiuxiu Lu
Venkata R. Sabbasani
Kylie J. Walters
ResearchOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1-18
Bipartite network models to design combination therapies in acute myeloid leukaemia

Identifying effective drug combinations to treat cancer is a challenging task, either experimentally or computationally. Here, the authors develop a bipartite network modelling approach to propose drug combination strategies in acute myeloid leukaemia using patient and cell line drug screening data.

Mohieddin Jafari
Mehdi Mirzaie
Jing Tang
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-12
Global variation in diabetes diagnosis and prevalence based on fasting glucose and hemoglobin A1c

Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

Bin Zhou
Kate E. Sheffer
Majid Ezzati
ResearchOpen Access09 Nov 2023
Nature Medicine

Volume: 29, P: 2885-2901
Repositioning of the global epicentre of non-optimal cholesterol

From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

Cristina Taddei
Bin Zhou
Majid Ezzati
ResearchOpen Access03 Jun 2020
Nature

Volume: 582, P: 73-77
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

A genetic study identifies hundreds of loci associated with risk tolerance and risky behaviors, finds evidence of substantial shared genetic influences across these phenotypes, and implicates genes involved in neurotransmission.

Richard Karlsson Linnér
Pietro Biroli
Jonathan P. Beauchamp
Research14 Jan 2019
Nature Genetics

Volume: 51, P: 245-257
Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Contrary to the view that urbanization is a major driver of the global rise in obesity, the global increase in body-mass index is shown to be mostly due to increases in the body-mass indexes of rural populations.

Honor Bixby
James Bentham
Majid Ezzati
ResearchOpen Access08 May 2019
Nature

Volume: 569, P: 260-264
Graph-based autoencoder integrates spatial transcriptomics with chromatin images and identifies joint biomarkers for Alzheimer’s disease

Methods for jointly analysing the different spatial data modalities in 3D are lacking. Here the authors report the computational framework STACI (Spatial Transcriptomic data using over-parameterized graph-based Autoencoders with Chromatin Imaging data) which they apply to an Alzheimer’s disease mouse model.

Xinyi Zhang
Xiao Wang
Caroline Uhler
ResearchOpen Access03 Dec 2022
Nature Communications

Volume: 13, P: 1-17
Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence

A natural language processing system can support physicians in diagnostic assessments by extracting clinical information from electronic medical records to accurately predict diagnosis in pediatric patients.

Huiying Liang
Brian Y. Tsui
Huimin Xia
Research11 Feb 2019
Nature Medicine

Volume: 25, P: 433-438
The finished DNA sequence of human chromosome 12

An analysis of the finished sequence of human chromosome 12 representing 4.5% of the human genome determines that chromosome 12 hosts a number of genes mutated in specific cancers, as well as movement disorders and potentially Alzheimer's disease.

Steven E. Scherer
Donna M. Muzny
Richard A. Gibbs
Research16 Mar 2006
Nature

Volume: 440, P: 346-351
Cytopathic SARS-CoV-2 screening on VERO-E6 cells in a large-scale repurposing effort

Andrea Zaliani
Laura Vangeel
Pieter Leyssen
ResearchOpen Access13 Jul 2022
Scientific Data

Volume: 9, P: 1-11
Cross-talk between primary osteocytes and bone marrow macrophages for osteoclastogenesis upon collagen treatment

Jeevithan Elango
Christelle Sanchez
Wenhui Wu
ResearchOpen Access28 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
Robust estimation of bacterial cell count from optical density

In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.

Jacob Beal
Natalie G. Farny
Jiajie Zhou
ResearchOpen Access17 Sept 2020
Communications Biology

Volume: 3, P: 1-29
Derivation of hypermethylated pluripotent embryonic stem cells with high potency

Siqin Bao
Walfred WC Tang
M Azim Surani
ResearchOpen Access27 Oct 2017
Cell Research

Volume: 28, P: 22-34
Author Correction: Robust estimation of bacterial cell count from optical density

Jacob Beal
Natalie G. Farny
Jiajie Zhou
Amendments and CorrectionsOpen Access27 Oct 2020
Communications Biology

Volume: 3, P: 1

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