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Showing 1–10 of 10 results

Advanced filters: Author: Caroline Jefferies Clear advanced filters

Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?

In this Opinion article, Caroline Jefferies and colleagues discuss the evidence in support of a role for TRIM proteins in autoimmune and autoinflammatory disease through their ability to regulate the inflammasome and pro-inflammatory cytokine and interferon production.

Caroline Jefferies
Claire Wynne
Rowan Higgs
Reviews25 Aug 2011
Nature Reviews Immunology

Volume: 11, P: 617-625
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

Inhibition of the tricarboxylic acid cycle enzyme fumarate hydratase leads to deregulation of cytokine production in macrophages, which has implications in human diseases such as systemic lupus erythematosus.

Alexander Hooftman
Christian G. Peace
Luke A. J. O’Neill
Research08 Mar 2023
Nature

Volume: 615, P: 490-498
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

Katherine A. Fitzgerald
Eva M. Palsson-McDermott
Luke A. J. O'Neill
Research06 Sept 2001
Nature

Volume: 413, P: 78-83
C9orf72 in myeloid cells suppresses STING-induced inflammation

Studies of mice and humans suggest a role for loss of the C9orf72 protein in some neurodegenerative disorders: with reduced C9orf72 levels, there is more inflammation mediated by the STING protein in immune and brain cells.

Madelyn E. McCauley
Jacqueline Gire O’Rourke
Robert H. Baloh
Research19 Aug 2020
Nature

Volume: 585, P: 96-101
Alterations in genes associated with cytosolic RNA sensing in whole blood are associated with coronary microvascular disease in SLE

Lihong Huo
Arati Naveen Kumar
Caroline Jefferies
ResearchOpen Access19 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Herpes simplex virus 1 targets IRF7 via ICP0 to limit type I IFN induction

David Shahnazaryan
Rana Khalil
Conor C. Murphy
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-10
The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection

Rebecca Mahony
Lindsay Broadbent
Caroline A. Jefferies
ResearchOpen Access06 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Externally validated deep learning model to identify prodromal Parkinson’s disease from electrocardiogram

Ibrahim Karabayir
Fatma Gunturkun
Oguz Akbilgic
ResearchOpen Access29 Jul 2023
Scientific Reports

Volume: 13, P: 1-9
miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome

Qistina Pilson
Siobhan Smith
Conor C. Murphy
ResearchOpen Access04 May 2020
Scientific Reports

Volume: 10, P: 1-11
TLR-induced activation of Btk – Role for endosomal MHC class II molecules revealed

Joan Ní Gabhann
Caroline A Jefferies
Research Highlights24 May 2011
Cell Research

Volume: 21, P: 998-1001