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Showing 1–3 of 3 results
Advanced filters: Author: Carrie Rinker-Schaeffer Clear advanced filters

  • Metastasis-suppressor genes (MSGs) are involved in diverse molecular processes in multiple tumor types; therefore, treatment strategies based on MSGs have unparalleled potential to improve patient care. In this Review, barriers specific to the translation of MSG biology into clinical practice are discussed and future research directions necessary for clinical advances are delineated.

    • Alexander N. Shoushtari
    • Russell Z. Szmulewitz
    • Carrie W. Rinker-Schaeffer
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 8, P: 333-342

  • Controlling the growth of cancer cells at metastatic sites is one goal of cancer drug development. Studies of metastasis suppressor function bring this long-sought goal closer (pages 933–938).

    • Carrie W Rinker-Schaeffer
    • Jonathan A Hickson
    News & Views
    Nature Medicine
    Volume: 12, P: 887-888

  • Krishnan et al. find that CCR1 ligands CCL6 and CCL23 secreted by murine and human macrophages, respectively, enhance metastatic colonization of ovarian cancer cells to the omentum in manner dependent on chemokine receptor 1 (CCR1). This study suggests that targeting CCR1 or CCL23 in ovarian cancer may be a therapeutic strategy.

    • Venkatesh Krishnan
    • Supreeti Tallapragada
    • Oliver Dorigo
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13