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Showing 1–5 of 5 results
Advanced filters: Author: Carsten Strohmann Clear advanced filters

  • Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them in the cell painting essays and identify the phenotypic role of individual fragments.

    • Michael Grigalunas
    • Annina Burhop
    • Herbert Waldmann
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • Design strategies that possess both biological relevance and structural diversity may lead to compound collections that are enriched in diverse bioactivities. Now a diverse pseudo-natural product design principle has been established to efficiently explore biologically relevant chemical space. Through dearomatization reactions, a compound collection enriched in both structural and biological diversity was rapidly generated.

    • Sukdev Bag
    • Jie Liu
    • Herbert Waldmann
    ResearchOpen Access
    Nature Chemistry
    Volume: 16, P: 945-958

  • Asymmetric systems for catalytic carbohydrate functionalization are mostly limited to chiral copper complexes and organocatalysts. Now, a synergistic chiral Rh(I)- and organoboron-catalysed site-selective functionalization of carbohydrate polyols has been developed, giving stereocontrolled access to biologically relevant arylhydronaphthalene glycosides. Enantio-, diastereo-, regio- and anomeric control and dynamic kinetic resolution were found to be concomitantly operative.

    • V. U. Bhaskara Rao
    • Caiming Wang
    • Charles C. J. Loh
    ResearchOpen Access
    Nature Chemistry
    Volume: 15, P: 424-435

  • Generating diverse structures with a minimum amount of synthetic effort is an important goal for drug discovery. Here, the authors report a two-phase synthesis for the generation of skeletally diverse small molecules—forming molecular scaffolds and subsequently diversifying each into multiple structures.

    • Miguel Garcia-Castro
    • Lea Kremer
    • Kamal Kumar
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • Synthetic methods that efficiently construct structurally diverse molecular scaffolds are attractive routes to diversely bioactive molecules. Here the authors report a method whereby common starting materials are converted to structurally and functionally diverse products by changing the catalyst ligand.

    • Yen-Chun Lee
    • Sumersing Patil
    • Herbert Waldmann
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12