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Showing 1–2 of 2 results
Advanced filters: Author: Cary S. Agler Clear advanced filters

  • Dental caries and periodontitis are among the most common medical conditions. Here, the authors report a GWAS for measures of oral health that reveals 47 risk loci for caries, find genetic correlation with 31 other complex traits and use Mendelian randomization analyses to explore potential causal relationships.

    • Dmitry Shungin
    • Simon Haworth
    • Ingegerd Johansson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo.

    • Steven Offenbacher
    • Yizu Jiao
    • Kari E. North
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17