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Showing 1–16 of 16 results
Advanced filters: Author: Caswell Barry Clear advanced filters

  • How neural responses to boundaries develop in the subiculum remains unknown. Here authors show that the receptive fields of Boundary Vector Cells (neurons signalling vector displacement to boundaries) are altered by environment geometry, with directional tunings aligning with square arena walls, including during development.

    • Laurenz Muessig
    • Fabio Ribeiro Rodrigues
    • Thomas J. Wills
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Rodents have an orientation map of their surroundings, produced and updated by a network of neurons in the entorhinal cortex known as 'grid cells'. However, it is currently unknown whether humans encode their location in a similar manner. Using functional magnetic resonance imaging in humans, a macroscopic signal representing a subject's position in a virtual reality environment is now detected that meets the criteria for defining grid-cell encoding.

    • Christian F. Doeller
    • Caswell Barry
    • Neil Burgess
    Research
    Nature
    Volume: 463, P: 657-661

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • Bellmund et al. use immersive virtual reality combined with successor representation modelling to show that environmental geometry distorts human spatial memory consistent with deformations of grid-cell firing patterns in navigating rodents.

    • Jacob L. S. Bellmund
    • William de Cothi
    • Christian F. Doeller
    Research
    Nature Human Behaviour
    Volume: 4, P: 177-188

  • Theories propose hippocampal memories are consolidated to the cortex during reactivation events known as replay. However, the involvement of the medial entorhinal cortex (MEC) in consolidation remains poorly understood. Ólafsdóttir et al. demonstrate coordinated replay between the hippocampus and MEC, with hippocampus leading, suggesting hippocampal memories are broadcast to MEC.

    • H Freyja Ólafsdóttir
    • Francis Carpenter
    • Caswell Barry
    Research
    Nature Neuroscience
    Volume: 19, P: 792-794

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • In this study, the authors show that the spatial responses of populations of grid cells are constrained to a two-dimensional activity manifold, and the relationships between pairs of grid cells are resistant to perturbation. These findings provide evidence of low-dimensional continuous attractor dynamics in the network.

    • KiJung Yoon
    • Michael A Buice
    • Ila R Fiete
    Research
    Nature Neuroscience
    Volume: 16, P: 1077-1084

  • A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

    • Erola Pairo-Castineira
    • Sara Clohisey
    • J. Kenneth Baillie
    Research
    Nature
    Volume: 591, P: 92-98

  • Neuronal grid cells fire in a spatial grid pattern laid out across the surface of a familiar environment, however the role of environmental boundaries in the construction of this pattern is not well understood; this study shows that the grid pattern orients to the walls of polarized environments such as squares but not circles and that the hexagonal grid symmetry is permanently broken in highly polarized environments such as trapezoids.

    • Julija Krupic
    • Marius Bauza
    • John O’Keefe
    Research
    Nature
    Volume: 518, P: 232-235