Chronic stress can lead to depression. Ronald Duman and his colleagues show that REDD1 expression is increased in the brain of patients with major depressive disorder and is upregulated in the brains of stressed mice. Mice lacking REDD1 were resistant to stress-induced depressive behaviors, and unstressed rats in which REDD1 was artificially increased exhibited depressive behaviors.
- Kristie T Ota
- Rong-Jian Liu
- Ronald S Duman
