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Calpain 3 deficiency is associated with myonuclear apoptosis and profound perturbation of the IκBα/NF-κB pathway in limb-girdle muscular dystrophy type 2A

Stephen Baghdiguian
Marianne Martin
Gérard Lefranc
Research01 May 1999
Nature Medicine

Volume: 5, P: 503-511
Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels

Exportin-5 is involved in microRNA precursor nuclear export. Dicer mRNA is now found to compete with pre-miRNAs for exportin-5 binding, suggesting that cytoplasmic levels of Dicer and its pre-miRNA substrate engage in a feedback loop. Analysis of adenoviral RNA indicates that it can also compete for exportin-5, suggesting that this might be a mechanism by which adenovirus can interfere with host miRNA processing.

Yamina Bennasser
Christine Chable-Bessia
Monsef Benkirane
Research06 Feb 2011
Nature Structural & Molecular Biology

Volume: 18, P: 323-327
Should I say or should I stop: raising your voice to influence science policy

In the current climate of cuts to science and research funding, the commitment of researchers to influencing science policy has resurfaced as an essential issue.

Catherine Dargemont
Comments & Opinion01 Jun 2011
Nature Cell Biology

Volume: 13, P: 635
Combining Spinach-tagged RNA and gene localization to image gene expression in live yeast

Measuring single-cell mRNA dynamics is critical to understand gene expression. Here, using RNA Spinach technique to detect very low abundant mRNAs, Guet et al. report an analysis of the osmotic shock response in live yeast by localizing induced transcription factors, target gene loci and corresponding transcripts.

David Guet
Laura T. Burns
Catherine Dargemont
ResearchOpen Access19 Nov 2015
Nature Communications

Volume: 6, P: 1-10
Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation

Mono-ubiquitylation of histone H2B is required for methylation of histone H3K4. Ubiquitylation of H2B in turn promotes ubiquitylation of Swd2, a component of the SET1/COMPASS methyltransferase. Inhibiting Swd2 ubiquitylation impairs recruitment of the COMPASS subunit, which is essential for methylation, and results in reduced H3K4 methylation.

Adeline Vitaliano-Prunier
Alexandra Menant
Catherine Dargemont
Research12 Oct 2008
Nature Cell Biology

Volume: 10, P: 1365-1371
The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS

Methylation of histone H3 lysine 4 (H3K4) by Set1/COMPASS occurs co-transcriptionally, and is important for gene regulation. Here the authors provide evidence that the Set1 N-terminal region and the COMPASS subunit Swd2 interact with RNA polymerase II CTD to recruit COMPASS in budding yeast.

Hyun Jin Bae
Marion Dubarry
Stephen Buratowski
ResearchOpen Access01 May 2020
Nature Communications

Volume: 11, P: 1-10
Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23

Mickaël Cohen
Françoise Stutz
Catherine Dargemont
Research02 Jun 2003
Nature Cell Biology

Volume: 5, P: 661-667
Expression of IκBα in the nucleus of human peripheral blood T lymphocytes

Teresa Laín de Lera
Lola Folgueira
José Alcami
Research08 Mar 1999
Oncogene

Volume: 18, P: 1581-1588

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