Nature Search

Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.

Samantha L. White
Maizy S. Brasher
Nikita Pozdeyev
ResearchOpen Access05 Feb 2026
Nature Genetics

Volume: 58, P: 307-316
The relationship between function and DNA sequence in an intercistronic regulatory region in phage λ

Martin Rosenberg
Donald Court
Daniel L. Wulff
Research01 Mar 1978
Nature

Volume: 272, P: 414-423
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards NK-like phenotype impairs T cell function and persistence

Relapsed and/or refractory acute myeloid leukemia (AML) postallogeneic hematopoietic cell transplantation has limited treatment options. Here the authors report the clinical results and immune correlates of a phase I/II trial of adoptively transferred virus-specific donor CD8 + T cells engineered to express a WT1-specific T cell receptor in patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation.

Francesco Mazziotta
Lauren E. Martin
Aude G. Chapuis
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-20
FDA penalizes trial misconduct

Catherine Shaffer
News01 Oct 2009
Nature Biotechnology

Volume: 27, P: 872
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology

Here authors show that machine learning derives the degree of background retinal pigmentation with more nuance than self-described ethnicity. Retinal pigment scores are associated with genes linked to melanin and may improve algorithmic fairness.

Anand E. Rajesh
Abraham Olvera-Barrios
Yalin Zheng
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-14
Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error

Transancestral GWAS meta-analysis in 160,420 individuals identifies 139 loci associated with refractive error, including myopia. Newly identified genes implicate pathways involved in eye growth and light signaling cascades.

Milly S. Tedja
Robert Wojciechowski
Caroline C. W. Klaver
Research28 May 2018
Nature Genetics

Volume: 50, P: 834-848
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits

Kelly et al. describe two cerebellum–thalamus–mPFC pathways in mice that regulate social and repetitive behavior. PC activation in Rcrus1 and posterior vermis improved social and reduced repetitive behaviors, respectively, in PC-Tsc1 mutant mice.

Elyza Kelly
Fantao Meng
Peter T. Tsai
Research13 Jul 2020
Nature Neuroscience

Volume: 23, P: 1102-1110
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin

Richard A. F. Dixon
Brian K. Kobilka
Catherine D. Strader
Research01 May 1986
Nature

Volume: 321, P: 75-79
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Molecular analysis of the association of HLA-B53 and resistance to severe malaria

Adrian V. S. Hill
John Elvin
Hilton C. Whittle
Reviews03 Dec 1992
Nature

Volume: 360, P: 434-439
Retinal vessel volume reference database derived from volume-rendered optical coherence tomography angiography

Silvia Feu-Basilio
Peter M. Maloca
Javier Zarranz-Ventura
ResearchOpen Access01 Feb 2024
Scientific Reports

Volume: 14, P: 1-8
Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells

Marie E. Egan
Judith Glöckner-Pagel
Michael J. Caplan
Research01 May 2002
Nature Medicine

Volume: 8, P: 485-492
Nested case–control study of the effects of non-steroidal anti-inflammatory drugs on breast cancer risk and stage

C R Sharpe
J-P Collet
J A Hanley
ResearchOpen Access06 Jun 2000
British Journal of Cancer

Volume: 83, P: 112-120
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Clinically applicable deep learning for diagnosis and referral in retinal disease

A novel deep learning architecture performs device-independent tissue segmentation of clinical 3D retinal images followed by separate diagnostic classification that meets or exceeds human expert clinical diagnoses of retinal disease.

Jeffrey De Fauw
Joseph R. Ledsam
Olaf Ronneberger
Research13 Aug 2018
Nature Medicine

Volume: 24, P: 1342-1350
Are we stuck in the standards?

To avoid duplication of effort, slow adoption and inefficiency in development, those developing biological standards need to communicate more with each other, attract help from experts in the ontology/standards communities and keep focused on needs of users.

Catherine A Ball
Comments & Opinion01 Nov 2006
Nature Biotechnology

Volume: 24, P: 1374-1376
A Novel ABC Transporter of the Sulfonylurea Receptor Family Expressed Specifically in the Drosophila Embryonic Heart and Tracheal System

Ayfer Alikasifoglu
Igor Nasonkin
Pamela Thomas
Research01 Apr 1999
Pediatric Research

Volume: 45, P: 84
Genome-wide analyses identify common variants associated with macular telangiectasia type 2

Melanie Bahlo and colleagues perform the first genome-wide association analysis for macular telangiectasia type 2. They identify three significant loci and report on a potential connection to the glycine/serine metabolism pathway.

Thomas S Scerri
Anna Quaglieri
Melanie Bahlo
Research27 Feb 2017
Nature Genetics

Volume: 49, P: 559-567
Composition, uniqueness and variability of the epiphytic bacterial community of the green alga Ulva australis

Catherine Burke
Torsten Thomas
Staffan Kjelleberg
Research04 Nov 2010
The ISME Journal

Volume: 5, P: 590-600
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Gut microbiota composition correlates with diet and health in the elderly

The microbial communities in the human intestine vary between individuals, and this variation is greater in older people; here it is shown that diet is the main factor that drives microbiota variation, which correlates with health.

Marcus J. Claesson
Ian B. Jeffery
Paul W. O’Toole
Research13 Jul 2012
Nature

Volume: 488, P: 178-184
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Convolutional neural network-based classification of glaucoma using optic radiation tissue properties

Kruper et al. investigate the impact of glaucoma on brain tissue by comparing MRI data from 856 people with glaucoma to matched controls without glaucoma. They find that neural networks using tissue properties from visual brain connections more accurately detect glaucoma than those trained on non-visual brain connections.

John Kruper
Adam Richie-Halford
Yalin Zheng
ResearchOpen Access11 Apr 2024
Communications Medicine

Volume: 4, P: 1-10
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

David J Hunter
Peter Kraft
Stephen J Chanock
Research27 May 2007
Nature Genetics

Volume: 39, P: 870-874
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

David Hunter and colleagues report results of the CGEMS multistage genome-wide association study of breast cancer. They identify two new risk variants on chromosomes 1p11.2 and 14q24.1, and confirm several previously reported breast cancer risk loci.

Gilles Thomas
Kevin B Jacobs
David J Hunter
Research29 Mar 2009
Nature Genetics

Volume: 41, P: 579-584
Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography

Peter M. Maloca
Silvia Feu-Basilio
Javier Zarranz-Ventura
ResearchOpen Access07 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Variability and abundance of the epiphytic bacterial community associated with a green marine Ulvacean alga

Niina A Tujula
Gregory R Crocetti
Staffan Kjelleberg
Research15 Oct 2009
The ISME Journal

Volume: 4, P: 301-311
Ezrin drives adaptation of monocytes to the inflamed lung microenvironment

Ravindra Gudneppanavar
Caterina Di Pietro
Emanuela M. Bruscia
ResearchOpen Access29 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-17
Author Correction: Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

Roberto Bonelli
Victoria E. Jackson
Melanie Bahlo
Amendments and CorrectionsOpen Access09 Apr 2021
Communications Biology

Volume: 4, P: 1
Host–microbe interactions as a driver of acclimation to salinity gradients in brown algal cultures

Simon M Dittami
Laëtitia Duboscq-Bidot
Thierry Tonon
Research26 Jun 2015
The ISME Journal

Volume: 10, P: 51-63
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Uncovering of intraspecies macular heterogeneity in cynomolgus monkeys using hybrid machine learning optical coherence tomography image segmentation

Peter M. Maloca
Christine Seeger
Nora Denk
ResearchOpen Access19 Oct 2021
Scientific Reports

Volume: 11, P: 1-15
Identification of genetic factors influencing metabolic dysregulation and retinal support for MacTel, a retinal disorder

Melanie Bahlo and colleagues report a genome-wide association study on the retinal degenerative disease Macular Telangiectasia Type 2, identifying 8 new genome-wide significant loci. Further analyses suggest key roles for genes that transport and synthesize the amino acids serine, glycine and alanine, providing a more accurate genomic tool for identifying people at risk of the disease.

Roberto Bonelli
Victoria E. Jackson
Melanie Bahlo
ResearchOpen Access02 Mar 2021
Communications Biology

Volume: 4, P: 1-14
Unraveling the deep learning gearbox in optical coherence tomography image segmentation towards explainable artificial intelligence

Maloca et al. implement convolutional neural network (CNN) to automatically segment OCT images obtained from cynomolgus monkeys. The results are compared to annotations generated by human graders. The ambiguity in ground truth had noteworthy impact on machine learning results, which could be visualized.

Peter M. Maloca
Philipp L. Müller
Nora Denk
ResearchOpen Access05 Feb 2021
Communications Biology

Volume: 4, P: 1-12
Re-evaluating diabetic papillopathy using optical coherence tomography and inner retinal sublayer analysis

Josef Huemer
Hagar Khalid
Pearse A. Keane
ResearchOpen Access09 Jul 2021
Eye

Volume: 36, P: 1476-1485
Systemic lipid dysregulation is a risk factor for macular neurodegenerative disease

Roberto Bonelli
Sasha M. Woods
Marcus Fruttiger
ResearchOpen Access22 Jul 2020
Scientific Reports

Volume: 10, P: 1-13
Replacing fishmeal with plant protein in Atlantic salmon (Salmo salar) diets by supplementation with fish protein hydrolysate

S. Egerton
A. Wan
C. Stanton
ResearchOpen Access06 Mar 2020
Scientific Reports

Volume: 10, P: 1-16
Validation of virtual reality orbitometry bridges digital and physical worlds

Peter M. Maloca
Balázs Faludi
Philippe C. Cattin
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
A virtual-clinic pathway for patients referred from a national diabetes eye screening programme reduces service demands whilst maintaining quality of care

Livia Faes
Dun Jack Fu
Dawn A. Sim
Research30 Oct 2020
Eye

Volume: 35, P: 2260-2269
Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

Colm MP O'Tuathaigh
Magdalena Hryniewiecka
John L Waddington
Research14 Jul 2010
Neuropsychopharmacology

Volume: 35, P: 2262-2273
AusTraits, a curated plant trait database for the Australian flora

Daniel Falster
Rachael Gallagher
Kasia Ziemińska
ResearchOpen Access30 Sept 2021
Scientific Data

Volume: 8, P: 1-20

Search

Filter By:

Search

Quick links