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Showing 1–3 of 3 results
Advanced filters: Author: Catherine L. Overed-Sayer Clear advanced filters

  • Roy et al. describe a generalized method for computationally designing miniproteins selective for a single integrin heterodimer and conformational state. The designed αvβ6 inhibitor remains monomeric and maintains biological activity following aerosolization and shows excellent efficacy in bleomycin induced lung fibrosis.

    • Anindya Roy
    • Lei Shi
    • David Baker
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • IL-33, released by epithelial cells in response to stress, is a potent activator of inflammation. Here Cohenet al. show that secreted IL-33 is rapidly inactivated by disulfide bond formation that prevents binding to its receptor, and that IL-33-related cytokines are susceptible to similar oxidation.

    • E. Suzanne Cohen
    • Ian C. Scott
    • Tomas Mustelin
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10