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Advanced filters: Author: Cecilia Lopez-Sambrooks Clear advanced filters

  • A high-throughput screen identifies NGI-1 as an inhibitor of oligosaccharyltransferase, preventing transfer of N-linked glycans to proteins. NGI-1 blocked EGFR signaling in non-small-cell lung cancer cell lines and promoted cell-cycle arrest and senescence.

    • Cecilia Lopez-Sambrooks
    • Shiteshu Shrimal
    • Joseph N Contessa
    Research
    Nature Chemical Biology
    Volume: 12, P: 1023-1030