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Showing 1–12 of 12 results
Advanced filters: Author: Cedric Govaerts Clear advanced filters

  • EPR spectroscopy analyses elucidate how lipids affect the conformational dynamics of a multidrug secondary transporter, LmrP, and indicate a key role of the lipid headgroups in shaping the conformational-energy landscape of the transporter.

    • Chloé Martens
    • Richard A Stein
    • Hassane S Mchaourab
    Research
    Nature Structural & Molecular Biology
    Volume: 23, P: 744-751

  • Substrate binding to the multidrug exporter LmrP from Lactococcus lactis catalyzes proton entrance by stabilizing an outward-open conformation. Transitions between conformational states are dictated by proton passage down the transmembrane helical bundle.

    • Matthieu Masureel
    • Chloé Martens
    • Cédric Govaerts
    Research
    Nature Chemical Biology
    Volume: 10, P: 149-155

  • Negatively charged lipids act as allosteric modulators for structural changes and activation of the GPCR β2-adrenergic receptor through direct intracellular interactions between lipid headgroups and the receptor.

    • Rosie Dawaliby
    • Cataldo Trubbia
    • Cédric Govaerts
    Research
    Nature Chemical Biology
    Volume: 12, P: 35-39

  • The leading cause of cystic fibrosis is the deletion of phenylalanine 508 (F508del) in the first nucleotide-binding domain (NBD1) of the cystic fibrosis transmembrane conductance regulator (CFTR). Here authors we develop nanobodies targeting NBD1 of human CFTR and demonstrate their ability to stabilize both isolated NBD1 and full-length protein.

    • Maud Sigoillot
    • Marie Overtus
    • Cedric Govaerts
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • The cystic fibrosis transmembrane conductance regulator anion channel can adopt an alternate conformation of its nucleotide-binding domain, which affects channel activity and, under certain conditions, leads to unfolding and protein degradation.

    • Daniel Scholl
    • Maud Sigoillot
    • Cédric Govaerts
    Research
    Nature Chemical Biology
    Volume: 17, P: 989-997

  • Blanpain and colleagues use inducible genetic lineage tracing to identify and follow the progenitors responsible for the development of the prostate glandular epithelium. They find that multipotent progenitors are initially able to differentiate into the three lineages that make up the prostate, with a later switch to distinct pools of unipotent basal and luminal stem cells.

    • Marielle Ousset
    • Alexandra Van Keymeulen
    • Cédric Blanpain
    Research
    Nature Cell Biology
    Volume: 14, P: 1131-1138

  • A crystal structure of bacterial multidrug transporter LmrP reveals the presence of a lipid inside the substrate binding cavity, with MD simulations and mutational analyses suggesting it could be involved in broad substrate specificity.

    • Vincent Debruycker
    • Andrew Hutchin
    • Cédric Govaerts
    Research
    Nature Structural & Molecular Biology
    Volume: 27, P: 829-835

  • A crystal structure of prokaryotic pentameric ligand-gated ion channel ELIC reveals a lipid-binding site at the interface between subunits that is shaped by a flexible helix important for channel desensitization upon lipid binding.

    • Camille M. Hénault
    • Cedric Govaerts
    • Chris Ulens
    Research
    Nature Chemical Biology
    Volume: 15, P: 1156-1164

  • Different key residues mediate melanocortin-4 receptor activation via the agonist αMSH or constitutive activation via interaction of the transmembrane domain with the N-terminal domain, and these modes are further distinguishable by the different effects of the physiological antagonist.

    • Baran A Ersoy
    • Leonardo Pardo
    • Christian Vaisse
    Research
    Nature Chemical Biology
    Volume: 8, P: 725-730

  • Cells at the origin of tumour initiation are unknown for many cancers. In hedgehog-induced basal cell carcinoma, skin hair-follicle stem cells do not participate to tumorigenesis, whereas Hedgehog activation in stem cells from the interfollicular epidermis does induce malignancy.

    • Khalil Kass Youssef
    • Alexandra Van Keymeulen
    • Cédric Blanpain
    Research
    Nature Cell Biology
    Volume: 12, P: 299-305