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Showing 1–4 of 4 results
Advanced filters: Author: Ceejay Lee Clear advanced filters

  • We show that gain-of-function cancer mutations in the KBTBD4 E3 ligase promote neodegradation of substrates via a shape-complementarity-based mechanism, which converges with the mechanism of action of the UM171 molecular glue degrader and can be blocked by HDAC1/2 inhibitors.

    • Xiaowen Xie
    • Olivia Zhang
    • Brian B. Liau
    ResearchOpen Access
    Nature
    Volume: 639, P: 241-249

  • Base editor technology combined with a fluorescent reporter of DNA methyltransferase activity enable in situ mutational scanning of DNMT3A, revealing a requirement of DNA binding by the PWWP histone reader domain for full activity.

    • Nicholas Z. Lue
    • Emma M. Garcia
    • Brian B. Liau
    Research
    Nature Chemical Biology
    Volume: 19, P: 176-186