Nature Search

Genetic variation in SCN10A influences cardiac conduction

John Chambers and colleagues report genome-wide association studies to several ECG measurements, identifying an association of SCN10A to PR interval. They find that Scn10a^−/− mice show a shorter PR interval.

John C Chambers
Jing Zhao
Jaspal S Kooner
Research10 Jan 2010
Nature Genetics

Volume: 42, P: 149-152
Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying the optimum sarcomere length for prolonged culturing, and investigating transcriptional profiles associated with functional preservation.

Samuel A. Watson
James Duff
Cesare M. Terracciano
ResearchOpen Access15 May 2019
Nature Communications

Volume: 10, P: 1-15
A SHIFT from ion channels to clinical practice

The 'funny' current (I_f) has been the subject of 30 years of laboratory research and is an important therapeutic target in heart disease owing to its effects on heart rate. SHIFT, a trial in patients with all-cause heart failure, shows that I_f inhibition reduces combined mortality and rate of hospitalization and opens further avenues of research and therapeutic challenges.

Cesare M. Terracciano
Magdi H. Yacoub
News & Views24 Nov 2010
Nature Reviews Cardiology

Volume: 7, P: 669-670
Preparation of viable adult ventricular myocardial slices from large and small mammals

This protocol describes how to obtain 100- to 400-μm-thick slices of a living myocardium from rodents, pigs, humans and dogs that retain the native multicellularity, architecture and physiology of the heart.

Samuel A Watson
Martina Scigliano
Filippo Perbellini
Protocols30 Nov 2017
Nature Protocols

Volume: 12, P: 2623-2639
Free-of-Acrylamide SDS-based Tissue Clearing (FASTClear) for three dimensional visualization of myocardial tissue

Filippo Perbellini
Alan K. L. Liu
Cesare M. Terracciano
ResearchOpen Access12 Jul 2017
Scientific Reports

Volume: 7, P: 1-9
Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials

Tatiana Trantidou
Cesare M. Terracciano
Themistoklis Prodromakis
ResearchOpen Access08 Jun 2015
Scientific Reports

Volume: 5, P: 1-13
Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices

Rasheda A. Chowdhury
Konstantinos N. Tzortzis
Nicholas S. Peters
ResearchOpen Access02 May 2018
Scientific Reports

Volume: 8, P: 1-13
Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

Yasunori Shintani
Hannes CA Drexler
Ken Suzuki
articlesOpen Access07 Mar 2014
EMBO reports

Volume: 15, P: 438-445
Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification

Carla Vicinanza
Iolanda Aquila
Daniele Torella
ResearchOpen Access11 Aug 2017
Cell Death & Differentiation

Volume: 24, P: 2101-2116

Search

Genetic variation in SCN10A influences cardiac conduction

Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

A SHIFT from ion channels to clinical practice

Preparation of viable adult ventricular myocardial slices from large and small mammals

Free-of-Acrylamide SDS-based Tissue Clearing (FASTClear) for three dimensional visualization of myocardial tissue

Biorealistic cardiac cell culture platforms with integrated monitoring of extracellular action potentials

Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices

Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification

Search

Quick links

Search

Filter By:

Search

Quick links