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Showing 1–4 of 4 results
Advanced filters: Author: Chad A. Zimprich Clear advanced filters

  • Murray et al. identified and characterized a small-molecule inhibitor of human COQ8A, which belongs to the UbiB protein family and is essential for coenzyme Q biosynthesis.

    • Nathan H. Murray
    • Christopher R. M. Asquith
    • David J. Pagliarini
    Research
    Nature Chemical Biology
    Volume: 19, P: 230-238

  • The use of NMR spectroscopy and development of a cellular BRET KRAS engagement assay revealed that noncovalent ligands can access the switch-II pocket of KRAS hotspot mutants.

    • James D. Vasta
    • D. Matthew Peacock
    • Kevan M. Shokat
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 596-604

  • Cyclin-dependent kinase (CDK) inhibitors are widely used both in the clinic and for basic research aimed at dissecting the specific cellular functions of specific CDKs. Here, the authors report the development of a panel of fluorescent reporter probes and provide a comprehensive profile of the inhibitory activity of several CDK inhibitors towards all 21 CDKs in living cells.

    • Carrow I. Wells
    • James D. Vasta
    • Matthew B. Robers
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Drug molecules operate through physical interaction with specific cellular targets, and understanding this interaction is important for mechanisms and the potential therapeutic effect of drug candidates. Here, the authors show that bioluminescence resonance energy transfer can be used to monitor the intracellular engagement of a drug with its target.

    • Matthew B. Robers
    • Melanie L. Dart
    • Keith V. Wood
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-10