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Advanced filters: Author: Chad M Renzelman Clear advanced filters

  • A single trimethylated species is obtained in an on-resin N-methylation reaction of a cyclic hexapeptide. This regioselectivity is driven by conformation and the presence of intramolecular hydrogen bonds, and is correlated with membrane permeability of the peptides.

    • Tina R White
    • Chad M Renzelman
    • R Scott Lokey
    Research
    Nature Chemical Biology
    Volume: 7, P: 810-817