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Showing 1–5 of 5 results
Advanced filters: Author: Champak Chatterjee Clear advanced filters

  • Semisynthetic methods to make ubiquitin conjugates have yielded broad conclusions for epigenetics. A robust intein-mediated chemical crosslinking strategy now expands our understanding by showing that a methyltransferase is surprisingly tolerant of changes to ubiquitin location and composition.

    • Champak Chatterjee
    • Robert K McGinty
    • Tom W Muir
    Research
    Nature Chemical Biology
    Volume: 6, P: 267-269

  • Chemical approaches to site-specifically ubiquitylate a target protein allow investigation of the biochemical effects of this modification, but they often destabilize the protein. Here, the authors report on a synthetic conjugation strategy that leads to protein ubiquitylation in non-denaturing conditions.

    • Caroline E. Weller
    • Abhinav Dhall
    • Champak Chatterjee
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Structural and functional analyses of BRCA1/BARD1 E3 ligase interactions with the H2A C-terminal tail reveal both the basis of its substrate specificity and the consequences of cancer-associated BRCA1/BARD1 mutations.

    • Samuel R. Witus
    • Anika L. Burrell
    • Rachel E. Klevit
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 268-277

  • Ubiquitylated histone H2B (uH2B) is a known chromatin modification involved in transcription. Analysis of nucleosome arrays containing chemically synthesized uH2B proteins revealed that this posttranslational modification impairs chromatin fiber compaction and increases its accessibility through a mechanism distinct from other chromatin marks.

    • Beat Fierz
    • Champak Chatterjee
    • Tom W Muir
    Research
    Nature Chemical Biology
    Volume: 7, P: 113-119