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Showing 1–4 of 4 results

Advanced filters: Author: Chance Meers Clear advanced filters

RNA-mediated double-strand break repair by end-joining mechanisms

Double-strand breaks (DSBs) in DNA are challenging to repair. Here, the authors show that transcript RNAs impact the DSB repair outcomes in human and yeast cells by promoting NHEJ or MMEJ in a sequence-specific manner, suggesting a direct role for RNA in modulating genome stability and evolution.

Youngkyu Jeon
Yilin Lu
Francesca Storici
ResearchOpen Access11 Sept 2024
Nature Communications

Volume: 15, P: 1-24
TnpB homologues exapted from transposons are RNA-guided transcription factors

RNA-guided transcription factors arose repeatedly via the domestication of transposon-encoded tnpB genes, representing a parallel evolutionary path to CRISPR-Cas adaptive immunity.

Tanner Wiegand
Florian T. Hoffmann
Samuel H. Sternberg
Research26 Jun 2024
Nature

Volume: 631, P: 439-448
Transposon-encoded nucleases use guide RNAs to promote their selfish spread

TnpB and IscB nucleases use transposon-encoded guide RNAs to target genomic sequences for cleavage, thereby favouring copying and spreading of transposable elements.

Chance Meers
Hoang C. Le
Samuel H. Sternberg
Research27 Sept 2023
Nature

Volume: 622, P: 863-871
Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons

Structural and phylogenetic analyses show that programmable RNA modifications ubiquitous in archaea and eukarya arose from bacterial transposons.

Hugo Vaysset
Chance Meers
Samuel H. Sternberg
Research02 Jan 2025
Nature Microbiology

Volume: 10, P: 20-27